血浆硫酸脱氢表雄酮与人格及应激反应相关。

Plasma dehydroepiandrosterone-sulphate is related to personality and stress response.

作者信息

do Vale Sónia, Martin Martins Joao, Fagundes Maria Joao, do Carmo Isabel

机构信息

Department of Endocrinology, Santa Maria Hospital, Lisbon, Portugal.

出版信息

Neuro Endocrinol Lett. 2011;32(4):442-8.

PMID:21876493

Abstract

OBJECTIVES

Dehydroepiandrosterone-sulphate (DHEAS) physiologic relevance remains controversial. However, several central nervous system and behavioural effects of DHEAS have been described. We explored the relation between DHEAS and both pituitary-adrenal axis reactivity and personality in human subjects.

DESIGN

We studied 120 consecutive patients assisted at the out patient endocrine department of a public central hospital before medical treatment. Personality was evaluated with the Minnesota Multiphasic Personality Inventory (MMPI) and the pituitary-adrenal axis reactivity was assessed with the CRH test.

RESULTS

Baseline DHEAS was inversely related to peak/basal cortisol (parcial r=-0.454, p<0.05) response to CRH infusion. DHEAS reactivity in the CRH test was directly related to the Deviant Behaviour triad (BD) (r=0.257, p<0.05) and type A personality (AP) (r=0.295, p<0.05). Basal ACTH was directly related to baseline DHEAS (r=0.366, p<0.001) and together with age and gender explained 34% of DHEAS variability.

CONCLUSIONS

DHEAS may be a protective factor against an excessive cortisol response when people are under stress situations. Personality may be related to DHEAS reactivity.

摘要

目的

硫酸脱氢表雄酮（DHEAS）的生理相关性仍存在争议。然而，已有多项关于DHEAS对中枢神经系统和行为影响的描述。我们探讨了人类受试者中DHEAS与垂体 - 肾上腺轴反应性及人格之间的关系。

设计

我们研究了120例在一家公立中心医院门诊内分泌科接受治疗前的连续患者。采用明尼苏达多相人格问卷（MMPI）评估人格，通过促肾上腺皮质激素释放激素（CRH）试验评估垂体 - 肾上腺轴反应性。

结果

基线DHEAS与CRH输注后皮质醇峰值/基础值反应呈负相关（偏相关系数r = -0.454，p < 0.05）。CRH试验中DHEAS的反应性与异常行为三联征（BD）（r = 0.257，p < 0.05）和A型人格（AP）（r = 0.295，p < 0.05）直接相关。基础促肾上腺皮质激素（ACTH）与基线DHEAS直接相关（r = 0.366，p < 0.001），年龄和性别与基础ACTH共同解释了DHEAS变异性的34%。