Straub R H, Vogl D, Gross V, Lang B, Schölmerich J, Andus T
Department of Internal Medicine I, University Medical Center, Regensburg, Germany.
Am J Gastroenterol. 1998 Nov;93(11):2197-202. doi: 10.1111/j.1572-0241.1998.00535.x.
Dehydroepiandrosterone sulfate (DHEAS) and cortisol are multifunctional adrenal hormones with immunomodulating properties. DHEAS levels were found to be very low in chronic inflammatory diseases. This study aimed to shed more light on the interrelation between DHEAS and cortisol (and humoral markers of inflammation) in chronic inflammatory bowel disease.
DHEAS and cortisol serum levels were measured by ELISA in the serum of 66 normal subjects, 115 patients with Crohn's disease (CD) and 64 patients with ulcerative colitis (UC). Humoral markers of inflammation and disease activity scores were assessed by standard techniques.
DHEAS was lower in patients with CD (p < 0.005) and UC (p < 0.005) than in controls, which was, in part, dependent on previous corticosteroid treatment (p < 0.01). In CD patients, z-normalized DHEAS was inversely correlated with blood sedimentation rate (p = 0.017). Z-normalized DHEAS was negatively correlated with interleukin-6 (IL-6) in the form of a trend (p = 0.068), and z-normalized DHEAS was significantly positively correlated with hemoglobin (p = 0.001) but not with the Crohn's disease activity index. Cortisol, however, was positively correlated with blood sedimentation rate (p = 0.034) and C-reactive protein (p = 0.006). In contrast, in UC patients no such correlation of z-normalized DHEAS or cortisol and parameters of humoral inflammatory activity or Rachmilewitz index exist.
DHEAS as a marker of inflammation was low in CD and UC. In CD patients, low DHEAS and high cortisol serum levels were associated with higher humoral inflammatory activity. With respect to humoral inflammatory activity in CD patients, DHEAS and cortisol seem to be inversely regulated, which may have an impact on several immune functions, such as IL-6 secretion.
硫酸脱氢表雄酮（DHEAS）和皮质醇是具有免疫调节特性的多功能肾上腺激素。研究发现，慢性炎症性疾病患者的DHEAS水平极低。本研究旨在进一步阐明慢性炎症性肠病中DHEAS与皮质醇（以及炎症的体液标志物）之间的相互关系。
采用酶联免疫吸附测定法（ELISA）检测66名正常受试者、115例克罗恩病（CD）患者和64例溃疡性结肠炎（UC）患者血清中的DHEAS和皮质醇水平。通过标准技术评估炎症的体液标志物和疾病活动评分。
CD患者（p < 0.005）和UC患者（p < 0.005）的DHEAS水平低于对照组，部分原因取决于先前的皮质类固醇治疗（p < 0.01）。在CD患者中，z标准化DHEAS与血沉率呈负相关（p = 0.017）。z标准化DHEAS与白细胞介素-6（IL-6）呈负相关趋势（p = 0.068），z标准化DHEAS与血红蛋白呈显著正相关（p = 0.001），但与克罗恩病活动指数无关。然而，皮质醇与血沉率（p = 0.034）和C反应蛋白（p = 0.006）呈正相关。相比之下，在UC患者中，z标准化DHEAS或皮质醇与体液炎症活动参数或拉赫米列维茨指数之间不存在这种相关性。
DHEAS作为炎症标志物，在CD和UC患者中水平较低。在CD患者中，低DHEAS和高皮质醇血清水平与更高的体液炎症活动相关。就CD患者的体液炎症活动而言，DHEAS和皮质醇似乎受到反向调节，这可能会对多种免疫功能产生影响，如IL-6分泌。
