Ganguly S, Salma K C, Kansakar I, Sharma M, Bastola P, Pradhan R
Birtamode Eye Hospital, Jhapa, Nepal.
Nepal J Ophthalmol. 2011 Jul-Dec;3(2):118-22. doi: 10.3126/nepjoph.v3i2.5262.
To find out the epidemiologic features in 686 consecutive cases of fungal keratitis presenting in a tertiary eye hospital in the western region of Nepal.
A prospective hospital - based study was carried out on 1880 consecutive patients presenting with corneal ulcer in the outpatient department and cornea clinic of Lumbini Eye Institute, Bhairawa, Nepal. The socio-demographic data, predisposing risk factors, prior treatment modalities, laboratory results and the distribution pattern of fungus species were analyzed.
Diagnosis of fungus keratitis was established in 686 (36 %) out of the total study group of 1880 cases. The spectrum of fungi isolated were Fusarium species (Fusarium spp.) in 219 (31.9 %), followed by unidentified dematiaceous 151 (22 %), curvularia 122 (17.7 %) and unidentified hyaline in 111 cases (16.1 %). Men (59.3 %) were more commonly affected than women (40.6 %). The young adults age group of 31-40 years was most commonly involved (26.6 %). Corneal trauma (58 %) and topical steroids (12 %) were the most common predisposing risk factors noted.
In contrast to the other studies done in Nepal, we found Fusarium to be the most common fungal isolate causing corneal ulcer followed by unidentified dematiaceous, unidentified hyaline and curvularia. Corneal trauma was the commonest predisposing risk factor in causing fungal keratitis.
了解尼泊尔西部地区一家三级眼科医院连续收治的686例真菌性角膜炎患者的流行病学特征。
在尼泊尔拜拉瓦的蓝毗尼眼科研究所门诊部和角膜诊所，对1880例连续就诊的角膜溃疡患者进行了一项基于医院的前瞻性研究。分析了社会人口统计学数据、诱发危险因素、既往治疗方式、实验室检查结果以及真菌种类的分布模式。
在1880例研究对象中，686例（36%）被确诊为真菌性角膜炎。分离出的真菌种类中，镰刀菌属（Fusarium spp.）219例（31.9%），其次是未鉴定的暗色真菌151例（22%），弯孢霉菌122例（17.7%），未鉴定的透明真菌111例（16.1%）。男性（59.3%）比女性（40.6%）更易患病。31 - 40岁的青年成年人最常受累（26.6%）。角膜外伤（58%）和局部使用类固醇（12%）是最常见的诱发危险因素。
与尼泊尔其他研究不同，我们发现镰刀菌是导致角膜溃疡最常见的真菌分离株，其次是未鉴定的暗色真菌、未鉴定的透明真菌和弯孢霉菌。角膜外伤是引起真菌性角膜炎最常见的诱发危险因素。
