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衰老、超负荷及肌酸补充对大鼠跖肌的相互作用

Interactions of aging, overload, and creatine supplementation in rat plantaris muscle.

作者信息

Schuenke Mark D, Brooks Naomi E, Hikida Robert S

机构信息

Department of Anatomy, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA.

出版信息

J Aging Res. 2011;2011:393416. doi: 10.4061/2011/393416. Epub 2011 Aug 11.

DOI:10.4061/2011/393416
PMID:21876808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3161242/
Abstract

Attenuation of age-related sarcopenia by creatine supplementation has been equivocal. In this study, plantaris muscles of young (Y; 5m) and aging (A; 24m) Fisher 344 rats underwent four weeks of either control (C), creatine supplementation (Cr), surgical overload (O), or overload plus creatine (OCr). Creatine alone had no effect on muscle fiber cross-sectional area (CSA) or heat shock protein (HSP70) and increased myonuclear domain (MND) only in young rats. Overload increased CSA and HSP70 content in I and IIA fibers, regardless of age, and MND in IIA fibers of YO rats. CSA and MND increased in all fast fibers of YOCr, and CSA increased in I and IIA fibers of AOCr. OCR did not alter HSP70, regardless of age. MND did not change in aging rats, regardless of treatment. These data indicate creatine alone had no significant effect. Creatine with overload produced no additional hypertrophy relative to overload alone and attenuated overload-induced HSP70 expression.

摘要

补充肌酸对与年龄相关的肌肉减少症的缓解作用一直存在争议。在本研究中，对年轻（Y；5个月）和老龄（A；24个月）的Fisher 344大鼠的比目鱼肌进行为期四周的对照（C）、补充肌酸（Cr）、手术性超负荷（O）或超负荷加肌酸（OCr）处理。单独补充肌酸对肌纤维横截面积（CSA）或热休克蛋白（HSP70）没有影响，且仅在年轻大鼠中增加了肌核域（MND）。无论年龄如何，超负荷均增加了I型和IIA型纤维中的CSA和HSP70含量，以及YO大鼠IIA型纤维中的MND。YOCr组所有快肌纤维的CSA和MND均增加，AOCr组I型和IIA型纤维的CSA增加。无论年龄如何，OCR均未改变HSP70。无论采用何种处理，老龄大鼠的MND均未改变。这些数据表明，单独补充肌酸没有显著作用。与单独超负荷相比，肌酸与超负荷联合使用并未产生额外的肥大作用，且减弱了超负荷诱导的HSP70表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db43/3161242/8b050c33c0ea/JAR2011-393416.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db43/3161242/dd1afcdefa59/JAR2011-393416.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db43/3161242/431418769c1c/JAR2011-393416.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db43/3161242/bc9f6e3cef98/JAR2011-393416.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db43/3161242/8b050c33c0ea/JAR2011-393416.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db43/3161242/dd1afcdefa59/JAR2011-393416.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db43/3161242/431418769c1c/JAR2011-393416.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db43/3161242/bc9f6e3cef98/JAR2011-393416.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db43/3161242/8b050c33c0ea/JAR2011-393416.004.jpg

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Am J Physiol Cell Physiol. 2010 Jan;298(1):C38-45. doi: 10.1152/ajpcell.00315.2009. Epub 2009 Oct 28.
2
Thermal preconditioning prevents fiber type transformation of the unloading induced-atrophied muscle in rats.热预处理可防止大鼠因卸载诱导萎缩的肌肉发生纤维类型转变。
J Muscle Res Cell Motil. 2009;30(3-4):145-52. doi: 10.1007/s10974-009-9183-z. Epub 2009 Jun 24.
3
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Acta Physiol (Oxf). 2009 Sep;197(1):55-63. doi: 10.1111/j.1748-1716.2009.01983.x. Epub 2009 Feb 28.
4
Dietary protein recommendations and the prevention of sarcopenia.膳食蛋白质推荐与肌肉减少症的预防
Curr Opin Clin Nutr Metab Care. 2009 Jan;12(1):86-90. doi: 10.1097/MCO.0b013e32831cef8b.
5
Sarcopenia accelerates at advanced ages in Fisher 344xBrown Norway rats.在费希尔344×布朗挪威大鼠中，肌肉减少症在老龄时加速发展。
J Gerontol A Biol Sci Med Sci. 2008 Sep;63(9):921-7. doi: 10.1093/gerona/63.9.921.
6
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Med Sci Sports Exerc. 2008 Sep;40(9):1645-52. doi: 10.1249/MSS.0b013e318176b310.
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Rejuvenation Res. 2008 Jun;11(3):641-7. doi: 10.1089/rej.2008.0699.
8
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Biogerontology. 2008 Aug;9(4):213-28. doi: 10.1007/s10522-008-9131-0. Epub 2008 Feb 26.
9
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Int J Sport Nutr Exerc Metab. 2007 Dec;17(6):624-34. doi: 10.1123/ijsnem.17.6.624.
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Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle.补充与不补充肌酸的抗阻运动对人体骨骼肌基因表达和细胞信号传导的影响。
J Appl Physiol (1985). 2008 Feb;104(2):371-8. doi: 10.1152/japplphysiol.00873.2007. Epub 2007 Nov 29.