Pavlishchuk S A
Cor Vasa. 1978;20(6):362-8.
The circadian rhythms of the functions of the cellular components of haemostasis, and their response to administration of ACTH, were studied in 30 healthy volunteers and in 17 patients with cardiosclerosis secondary to past myocardial infarction. A biphasic periodicity was found of the counts and functional activities of thrombocytes and basophilic leukocytes during 24-h periods. The phase of peak activities of both formed blood elements was established between 11.00 and 14.00 hours; in the night their functional capacities were lower than in the morning. Administration of ACTH elicited analogous shifts in the above mentioned indicators, but with a faster development of the first phase. In ischaemic heart disease the normal circadian rhythm of functions of the specified indicators was disturbed, and they exhibited signs of inertia, which phenomenon, in the author's opinion, reflects a lowered reliability of function of the haemostatic system.
在30名健康志愿者和17名既往心肌梗死继发的心硬化患者中，研究了止血细胞成分功能的昼夜节律及其对促肾上腺皮质激素给药的反应。在24小时期间，发现血小板和嗜碱性白细胞的计数及功能活动呈双相周期性。两种血液成分的活动高峰阶段在11:00至14:00之间；夜间它们的功能能力低于早晨。促肾上腺皮质激素给药引起上述指标类似的变化，但第一阶段发展更快。在缺血性心脏病中，特定指标功能的正常昼夜节律受到干扰，且表现出惰性迹象，作者认为，这一现象反映了止血系统功能可靠性降低。
