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乔治三世国王与卟啉病:对历史证据的临床重新审视

King George III and porphyria: a clinical re-examination of the historical evidence.

作者信息

Peters Timothy J, Wilkinson D

机构信息

Institute of Archaeology and Antiquity, University of Birmingham.

出版信息

Hist Psychiatry. 2010 Mar;21(81 Pt 1):3-19. doi: 10.1177/0957154X09102616.

DOI:10.1177/0957154X09102616
PMID:21877427
Abstract

The diagnosis that George III suffered from acute porphyria has gained widespread acceptance,but re-examination of the evidence suggests it is unlikely that he had porphyria.The porphyria diagnosis was advanced by Ida Macalpine and Richard Hunter, whose clinical symptomatology and historical methodology were flawed.They highlighted selected symptoms, while ignoring, dismissing or suppressing counter-evidence.Their claims about peripheral neuropathy, cataracts, vocal hoarseness and abdominal pains are re-evaluated; and it is also demonstrated that evidence of discoloured urine is exceedingly weak. Macalpine and Hunter believed that mental illnesses were primarily caused by physical diseases, and their diagnosis of George III formed part of a wider agenda to promote controversial views about past, contemporary and future methods in psychiatry.

摘要

乔治三世患有急性卟啉病这一诊断已被广泛接受,但对证据的重新审视表明他不太可能患有卟啉病。卟啉病的诊断是由艾达·麦卡尔平(Ida Macalpine)和理查德·亨特(Richard Hunter)提出的,他们的临床症状学和历史研究方法存在缺陷。他们突出了某些特定症状,而忽略、摒弃或压制了反证。他们关于周围神经病变、白内障、声音嘶哑和腹痛的说法被重新评估;同时也表明尿液变色的证据极其薄弱。麦卡尔平和亨特认为精神疾病主要由身体疾病引起,他们对乔治三世的诊断是推动关于精神病学过去、当代和未来方法的有争议观点这一更广泛议程的一部分。

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King George III and porphyria: a clinical re-examination of the historical evidence.乔治三世国王与卟啉病:对历史证据的临床重新审视
Hist Psychiatry. 2010 Mar;21(81 Pt 1):3-19. doi: 10.1177/0957154X09102616.
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The madness of King George III: a psychiatric re-assessment.《乔治三世国王的疯狂:一项精神病学重新评估》
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FitzPatrick Lecture: King George III and the porphyria myth - causes, consequences and re-evaluation of his mental illness with computer diagnostics.菲茨帕特里克讲座:乔治三世国王与卟啉症神话——利用计算机诊断对其精神疾病的病因、后果及重新评估
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