Molecular Design Institute, Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA.
Anal Chem. 2011 Oct 1;83(19):7444-50. doi: 10.1021/ac201570r. Epub 2011 Aug 30.
Counterfeit pharmaceutical products are a global threat to public health, and they undermine the credibility and the financial success of the producers of genuine products. The escalating circulation of counterfeit drugs demands new anticounterfeit measures that permit rapid screening, are nondestructive, and cannot be circumvented easily. Herein we describe a micro-X-ray diffraction (μ-XRD) protocol for this purpose capable of reading barcodes and logos fabricated on various substrates using soft-lithography stamping of compounds that can be read by X-ray diffraction but are invisible to the naked eye or optical microscopy. This method is demonstrated with barcodes and logos of compounds, approved by the Food and Drug Administration, printed on flat substrates as well as commercial aspirin and ibuprofen tablets. The μ-XRD protocol is nondestructive, automated, and user-friendly and can be used to certify the authenticity of drug tablets by mapping hidden patterns printed under the tablet coating and on packages.
假冒药品是对全球公众健康的一种威胁，而且它们还会破坏正品药品生产者的信誉和经济利益。日益泛滥的假冒药品需要采取新的防伪措施，这些措施需要能够快速筛查、无损且不易被规避。为此，我们描述了一种微 X 射线衍射（μ-XRD）方案，它使用化合物的软光刻压印技术在各种基底上制造可通过 X 射线衍射读取但肉眼或光学显微镜不可见的条形码和徽标。该方法使用在平面基底以及商业阿司匹林和布洛芬片剂上打印的经食品和药物管理局批准的化合物条形码和徽标进行了演示。μ-XRD 方案是非破坏性的、自动化的和用户友好的，可用于通过在片剂涂层下和包装上打印隐藏图案来映射，从而认证药物片剂的真伪。
