Hatch Fiona, Lancaster Matthew K, Jones Sandra A
Biological Sciences and HYMS, University of Hull, Kingston-Upon-Hull, UK.
Expert Rev Cardiovasc Ther. 2011 Aug;9(8):1059-67. doi: 10.1586/erc.11.112.
Aging is an inevitable time-dependent progression associated with a functional decline of the cardiovascular system even in 'healthy' individuals. Age positively correlates with an increasing risk of cardiac problems including arrhythmias. Not only the prevalence but also the severity of arrhythmias escalates with age. The reasons for this are multifactorial but dysregulation of intracellular calcium within the heart is likely to play a key role in initiating and perpetuating these life-threatening events. We now know that several aspects of cardiac calcium regulation significantly change with advancing age - changes that could produce electrical instability. Further development of knowledge of the mechanisms underlying these changes will allow us to reduce what currently is an inevitable increase in the incidence of arrhythmias in the elderly.
衰老 是一种不可避免的随时间推移的进程，即使在 “健康” 个体中，也与心血管系统功能衰退相关。年龄与包括心律失常在内的心脏问题风险增加呈正相关。心律失常的患病率和严重程度均随年龄增长而上升。其原因是多方面的，但心脏内细胞内钙的调节失调可能在引发和持续这些危及生命的事件中起关键作用。我们现在知道，随着年龄的增长，心脏钙调节的几个方面会发生显著变化，这些变化可能导致电不稳定。进一步了解这些变化背后的机制，将使我们能够降低目前老年人心律失常发病率不可避免的上升。
