内体成熟。
Endosome maturation.
机构信息
Institute of Biochemistry, ETH Zurich, Switzerland.
出版信息
EMBO J. 2011 Aug 31;30(17):3481-500. doi: 10.1038/emboj.2011.286.
Abstract
Being deeply connected to signalling, cell dynamics, growth, regulation, and defence, endocytic processes are linked to almost all aspects of cell life and disease. In this review, we focus on endosomes in the classical endocytic pathway, and on the programme of changes that lead to the formation and maturation of late endosomes/multivesicular bodies. The maturation programme entails a dramatic transformation of these dynamic organelles disconnecting them functionally and spatially from early endosomes and preparing them for their unidirectional role as a feeder pathway to lysosomes.
摘要
作为与信号转导、细胞动态、生长、调控和防御密切相关的过程，内吞作用与细胞生命和疾病的几乎所有方面都有关联。在这篇综述中，我们聚焦于经典内吞途径中的内体，以及导致晚期内体/多泡体形成和成熟的变化方案。成熟方案涉及这些动态细胞器的剧烈转变，使它们在功能和空间上与早期内体分离，并使它们准备好作为溶酶体的单向进料途径发挥作用。
相似文献
1
Endosome maturation.
EMBO J. 2011 Aug 31;30(17):3481-500. doi: 10.1038/emboj.2011.286.
2
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.
Nat Cell Biol. 2008 Jul;10(7):776-87. doi: 10.1038/ncb1740. Epub 2008 Jun 15.
3
Early Endosome Morphology in Health and Disease.
Adv Exp Med Biol. 2018;1074:335-343. doi: 10.1007/978-3-319-75402-4_41.
4
ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis.
Autophagy. 2019 Jan;15(1):34-57. doi: 10.1080/15548627.2018.1507438. Epub 2018 Sep 13.
5
Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation.
Traffic. 2016 Nov;17(11):1181-1196. doi: 10.1111/tra.12431. Epub 2016 Oct 3.
6
Different microtubule motors move early and late endocytic compartments.
Traffic. 2008 Apr;9(4):492-509. doi: 10.1111/j.1600-0854.2008.00704.x. Epub 2008 Jan 10.
7
Inhibition of autophagy and multiple steps in asialoglycoprotein endocytosis by inhibitors of tyrosine protein kinases (tyrphostins).
J Biol Chem. 1995 May 26;270(21):12823-31. doi: 10.1074/jbc.270.21.12823.
8
ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.
Cell Struct Funct. 2012;37(2):141-54. doi: 10.1247/csf.12015. Epub 2012 Sep 5.
9
The recycling endosome protein RAB-10 promotes autophagic flux and localization of the transmembrane protein ATG-9.
Autophagy. 2017 Oct 3;13(10):1742-1753. doi: 10.1080/15548627.2017.1356976. Epub 2017 Sep 5.
10
Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos.
Nat Commun. 2012;3:1071. doi: 10.1038/ncomms2069.
引用本文的文献
1
Urinary exosomal RAB11A serves as a novel non-invasive biomarker for diagnosis, treatment response monitoring, and prognosis in small cell lung cancer.
Clin Proteomics. 2025 Aug 25;22(1):30. doi: 10.1186/s12014-025-09554-4.
2
Triclabendazole suppresses cellular levels of glycosaminoglycan-A potential therapeutic agent for mucopolysaccharidoses and related diseases.
iScience. 2025 Jul 18;28(8):113118. doi: 10.1016/j.isci.2025.113118. eCollection 2025 Aug 15.
3
Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing.
bioRxiv. 2025 Jul 22:2025.07.22.665497. doi: 10.1101/2025.07.22.665497.
4
Dual-transcriptomics on microdissected cells reveals functional specialisation of symbiont-bearing-cells and contrasted responses to nutritional stress in the cereal weevil.
Microbiome. 2025 Aug 6;13(1):182. doi: 10.1186/s40168-025-02164-0.
5
Lysosomal membrane homeostasis and its importance in physiology and disease.
Nat Rev Mol Cell Biol. 2025 Aug 4. doi: 10.1038/s41580-025-00873-w.
6
Engineered lipid nanoparticles with synergistic dendritic cell targeting and enhanced endosomal escape for boosted mRNA cancer vaccines.
Mater Today Bio. 2025 Jul 19;34:102107. doi: 10.1016/j.mtbio.2025.102107. eCollection 2025 Oct.
7
DNAJC13 localization to endosomes is opposed by its J domain and its disordered C-terminus.
Mol Biol Cell. 2025 Sep 1;36(9):ar114. doi: 10.1091/mbc.E24-12-0575. Epub 2025 Jul 30.
8
Microfluidic Devices for Manufacture of Therapeutic Extracellular Vesicles: Advances and Opportunities.
J Extracell Vesicles. 2025 Jul;14(7):e70132. doi: 10.1002/jev2.70132.
9
Rational design of lipid nanoparticles for enabling gene therapies.
Mol Ther Methods Clin Dev. 2025 Jun 18;33(3):101518. doi: 10.1016/j.omtm.2025.101518. eCollection 2025 Sep 11.
10
ESCRTing the RABs through conversion.
Biochem Soc Trans. 2025 Apr 30;53(2):431-445. doi: 10.1042/BST20253007.
本文引用的文献
1
Fission of tubular endosomes triggers endosomal acidification and movement.
PLoS One. 2011 May 10;6(5):e19764. doi: 10.1371/journal.pone.0019764.
2
Endocytosis and signaling.
Curr Opin Cell Biol. 2011 Aug;23(4):393-403. doi: 10.1016/j.ceb.2011.03.008. Epub 2011 Apr 5.
3
Microautophagy of cytosolic proteins by late endosomes.
Dev Cell. 2011 Jan 18;20(1):131-9. doi: 10.1016/j.devcel.2010.12.003.
4
Multivesicular bodies in neurons: distribution, protein content, and trafficking functions.
Prog Neurobiol. 2011 Mar;93(3):313-40. doi: 10.1016/j.pneurobio.2011.01.003. Epub 2011 Jan 7.
5
Ion flux and the function of endosomes and lysosomes: pH is just the start: the flux of ions across endosomal membranes influences endosome function not only through regulation of the luminal pH.
Bioessays. 2011 Feb;33(2):103-10. doi: 10.1002/bies.201000108.
6
Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation.
J Cell Biol. 2010 Nov 1;191(3):615-29. doi: 10.1083/jcb.201003086.
7
Rubicon controls endosome maturation as a Rab7 effector.
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19338-43. doi: 10.1073/pnas.1010554107. Epub 2010 Oct 25.
8
Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain.
Mol Biol Cell. 2010 Dec;21(23):4162-72. doi: 10.1091/mbc.E10-06-0495. Epub 2010 Oct 13.
9
Endocytosis in filamentous fungi: Cinderella gets her reward.
Curr Opin Microbiol. 2010 Dec;13(6):684-92. doi: 10.1016/j.mib.2010.09.005. Epub 2010 Oct 1.
10
Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons.
Neuron. 2010 Oct 6;68(1):73-86. doi: 10.1016/j.neuron.2010.09.022.
Zotero 插件