Ottenweller J E, Meier A H, Ferrell B R, Horseman N D, Proctor A
Endocrinology. 1978 Nov;103(5):1875-9. doi: 10.1210/endo-103-5-1875.
Intravascular injections of adrenocorticotropic hormone in hypophysectomized rats were approximately 3 times more effective in stimulating increases in plasma corticosteroid concentration when given at the offset rather than the onset of the daily photoperiod (12 h:12 h light-dark cycle). Reversal of the photoperiodic schedule produced a reversal in the corticosteroid response after 5 days. Similar temporal variations in androgen and T4 responses to LH and TSH were not obtained. Although plasma corticosteroid concentrations were maintained at normal intermediate levels in rats with adrenal autotransplants, daily variations were not demonstrable. These results indicate that the circadian rhythm of plasma corticosteroid concentration is regulated by way of neural pathways to the adrenal.
在切除垂体的大鼠中，当在每日光周期（12小时光照-12小时黑暗循环）结束时而不是开始时进行促肾上腺皮质激素的血管内注射，刺激血浆皮质类固醇浓度增加的效果约为3倍。光周期时间表的颠倒在5天后导致皮质类固醇反应的颠倒。未观察到雄激素和T4对促黄体生成素和促甲状腺激素反应的类似时间变化。尽管在肾上腺自体移植的大鼠中血浆皮质类固醇浓度维持在正常中间水平，但未显示出每日变化。这些结果表明，血浆皮质类固醇浓度的昼夜节律是通过通往肾上腺的神经通路调节的。
