Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, 201 Section 2 Shih-Pai Road, Taipei, 11217, Taiwan.
World J Surg. 2011 Nov;35(11):2472-8. doi: 10.1007/s00268-011-1247-8.
Despite curative surgery for gastric cancer, many patients die of recurrent cancer. Few studies have investigated the time to recurrence after curative resection for gastric cancer.
Data were collected prospectively between December 1987 and December 2006. A total of 1,549 patients underwent curative resection of adenocarcinoma of the stomach at Taipei Veterans General Hospital. Among them, 419 patients had recurrence; they were divided into early recurrence (<2 years) and late recurrence (≥2 years). The clinicopathological characteristics, survival time after recurrence, and recurrence patterns were compared between the two groups.
Multivariate analysis showed that stage III gastric cancer patients with early recurrence had larger tumors and more lymph node metastasis than patients with late recurrence, while no difference between early and late recurrence was observed in stage I and II patients. Early recurrence was associated with more distant metastasis than was late recurrence. Patients with advanced TNM stage tended to die within 2 years after recurrence.
Gastric cancer patients with larger tumors and more lymph node metastasis tended to have early recurrence, especially stage III patients. Advanced TNM stage was associated with early cancer death after recurrence.
尽管胃癌的治愈性手术可以根治肿瘤，但仍有许多患者死于肿瘤复发。鲜有研究调查过胃癌根治性切除术后的复发时间。
数据于 1987 年 12 月至 2006 年 12 月期间前瞻性收集。共有 1549 例在台北荣民总医院接受胃腺癌治愈性切除术的患者。其中，419 例患者复发；他们被分为早期复发（<2 年）和晚期复发（≥2 年）。比较两组患者的临床病理特征、复发后生存时间和复发模式。
多因素分析显示，III 期早期复发胃癌患者的肿瘤较大，淋巴结转移较多，而 I 期和 II 期患者的早期和晚期复发之间无差异。早期复发与远处转移的相关性高于晚期复发。晚期 TNM 分期的患者倾向于在复发后 2 年内死亡。
肿瘤较大且淋巴结转移较多的胃癌患者更易发生早期复发，尤其是 III 期患者。晚期 TNM 分期与复发后早期癌症死亡相关。
