Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University Medical Group, Greenville Hospital System, Greenville, SC 29605, USA.
Fertil Steril. 2011 Sep;96(3):522-9. doi: 10.1016/j.fertnstert.2011.07.1095.
To provide a focused review of the scientific literature pertaining to endometrial receptivity.
Review of the literature and appraisal of relevant articles.
Academic teaching hospital.
PATIENT(S): Women with infertility.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Critical review of the literature.
RESULT(S): Although a consensus has been achieved regarding the existence of a temporally defined period during which embryo attachment and invasion can occur (called the "window of implantation"), reliable methods to assess "receptivity" have not been established or adequately validated. In women with certain gynecologic disorders, including endometriosis, tubal disease, and polycystic ovary syndrome, endometrial receptivity seems to be compromised, leading to infertility and pregnancy loss. The establishment of reliable biomarkers for the detection of defects in endometrial receptivity has been a long-sought goal that remains an elusive target. The validation of endometrial biomarkers will require properly designed and implemented studies based on the recognition that endometrial receptivity defects are not equally distributed in women with endometriosis or these other conditions.
CONCLUSION(S): Rapidly advancing technologies are bringing new biomarkers to the clinical arena that promise to further reveal the complexities of the implantation process.
对与子宫内膜容受性相关的科学文献进行重点综述。
文献回顾和相关文章评估。
学术教学医院。
不孕妇女。
无。
文献批判性评价。
尽管已经达成共识，即胚胎附着和侵入可以发生在一个时间定义的时期（称为“着床窗口”），但评估“容受性”的可靠方法尚未建立或充分验证。在某些妇科疾病患者中，包括子宫内膜异位症、输卵管疾病和多囊卵巢综合征，子宫内膜容受性似乎受到损害，导致不孕和妊娠丢失。建立可靠的子宫内膜容受性检测生物标志物一直是一个长期追求的目标，但仍然难以实现。子宫内膜生物标志物的验证将需要基于这样的认识，即基于设计和实施的研究，即子宫内膜容受性缺陷在子宫内膜异位症或其他这些情况下的妇女中并非均匀分布。
快速发展的技术正在将新的生物标志物推向临床领域，有望进一步揭示着床过程的复杂性。
