Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Fertil Steril. 2011 Sep;96(3):594-9. doi: 10.1016/j.fertnstert.2011.06.071.
To evaluate the association of antral follicle count (AFC) with in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) outcome in a large unselected cohort of patients covering the entire range of AFC.
Prospective observational study.
University-affiliated private infertility center.
PATIENT(S): 2,092 women undergoing 4,308 IVF-ICSI cycles.
INTERVENTION(S): AFC analyzed for associations with treatment outcome and statistically adjusted for repeated treatments and age.
MAIN OUTCOME MEASURE(S): Pregnancy rate, live-birth rate, and stimulation outcome parameters.
RESULT(S): The AFC was log-normally distributed. Pregnancy rates and live-birth rates were positively associated with AFC in a log-linear way, leveling out above AFC ∼30. Treatment outcome was superior among women with polycystic ovaries, independent from ovulatory status. The findings were significant also after adjustment for age and number of oocytes retrieved.
CONCLUSION(S): Pregnancy and live-birth rates are log-linearly related to AFC. Polycystic ovaries, most often excluded from studies on ovarian reserve, fit as one extreme in the spectrum of AFC; a low count constitutes the other extreme, with the lowest ovarian reserve and poor treatment outcome. The findings remained statistically significant also after adjustment for the number of oocytes retrieved, suggesting this measure of ovarian reserve comprises information on oocyte quality and not only quantity.
评估窦卵泡计数（AFC）与体外受精/胞浆内单精子注射（IVF-ICSI）结局的相关性，该研究纳入了涵盖整个 AFC 范围的大量未经选择的患者队列。
前瞻性观察性研究。
大学附属私立不孕不育中心。
2092 名接受 4308 次 IVF-ICSI 周期的女性。
分析 AFC 与治疗结局的相关性，并对重复治疗和年龄进行统计学调整。
妊娠率、活产率和刺激结局参数。
AFC 呈对数正态分布。妊娠率和活产率与 AFC 呈对数线性相关，在 AFC ∼30 以上趋于平稳。多囊卵巢患者的治疗结局优于排卵状态，且不受排卵状态影响。即使在调整年龄和获卵数后，这些发现仍然具有统计学意义。
妊娠率和活产率与 AFC 呈对数线性相关。多囊卵巢，通常被排除在卵巢储备研究之外，是 AFC 谱中的一个极端；低计数是另一个极端，代表最低的卵巢储备和较差的治疗结局。即使在调整获卵数后，这些发现仍具有统计学意义，表明这种卵巢储备测量指标不仅包含卵子数量，还包含卵子质量的信息。
