Center for Reproductive Medicine, Jean Verdier Hospital, University Paris XIII, Paris, France.
Fertil Steril. 2011 Sep;96(3):600-4. doi: 10.1016/j.fertnstert.2011.06.061.
To assess the relationship between endogenous LH serum levels after GnRH analogue administration and serum P elevation on the day of hCG administration (P hCG).
Retrospective study.
Reproductive medicine center in a university hospital.
PATIENT(S): A total of 708 patients undergoing a GnRH agonist or antagonist protocol for IVF intracytoplasmic sperm injection.
INTERVENTION(S): Controlled ovarian stimulation.
MAIN OUTCOME MEASURE(S): Serum P values according to GnRH analogue; correlation between serum LH measurements and P hCG values.
RESULT(S): Serum P hCG values were significantly lower following the GnRH antagonist than agonist protocol. A positive correlation between serum P hCG and LH area under the curve or day 6 LH values was found in the GnRH agonist group and between P hCG and LH hCG levels in both GnRH analogue regimens. With multivariate analysis, P hCG values were positively correlated with serum E(2) levels on hCG administration day and with the total FSH dose in both GnRH analogue-treated groups. Additionally, the correlation between serum P hCG and LH hCG values was positive in patients treated with the GnRH agonist protocol.
CONCLUSION(S): The lower serum P levels on hCG administration day following the GnRH antagonist protocol are mainly explained by lower granulosa cell steroidogenic activity. The correlation with serum LH hCG values was positive in the GnRH agonist-treated group.
评估 GnRH 类似物给药后血清内源性 LH 水平与 hCG 给药日（P hCG）血清 P 升高之间的关系。
回顾性研究。
大学医院生殖医学中心。
共 708 例接受 GnRH 激动剂或拮抗剂方案进行 IVF 胞浆内精子注射的患者。
控制性卵巢刺激。
根据 GnRH 类似物的血清 P 值；血清 LH 测量值与 P hCG 值之间的相关性。
与 GnRH 激动剂方案相比， GnRH 拮抗剂方案后的血清 P hCG 值明显较低。在 GnRH 激动剂组中，血清 P hCG 与 LH 曲线下面积或第 6 天 LH 值呈正相关，在两种 GnRH 类似物方案中，P hCG 与 LH hCG 值之间存在正相关。多元分析显示，在 GnRH 类似物治疗组中，P hCG 值与 hCG 给药日血清 E2 水平和总 FSH 剂量呈正相关。此外，在 GnRH 激动剂治疗组中，血清 P hCG 与 LH hCG 值之间的相关性为正相关。
GnRH 拮抗剂方案中 hCG 给药日血清 P 水平较低，主要是由于颗粒细胞甾体生成活性较低。在 GnRH 激动剂治疗组中，与血清 LH hCG 值呈正相关。
