Poirier S, Auger P, Joly J, Steben M
Department of Microbiology and Immunology, University of Montreal, Quebec, Canada.
Mycoses. 1990 Jan;33(1):24-8. doi: 10.1111/myc.1990.33.1.24.
Chronic vulvovaginitis due to Candida albicans is a major clinical problem for the physician. Although new antifungal drugs are now available, the therapeutic approach of this disease remains disappointing. The aims of this study were two-fold. First, we wanted to evaluate the reliability of a single sampling performed by most clinicians in verifying if the yeast infects the entire genital mucosa or a preferential site and, second, to biotype the strains recovered in order to see if more than one strain are responsible for the infection. We found, in 18 patients suffering from vaginal candidosis, that the entire genital mucosa was infected by the yeast and the strain recovered from the different genital sites in a single patient was the same in 100% of the cases. Only 1.4% of the samples were negative. In addition, we biotyped the strains obtained from the gastrointestinal tract of these patients to evaluate this site as a potential source of infection. We obtained gastrointestinal tract samples for 15 of the 18 patients and we could identify C. albicans in 100% of the cases. Furthermore, 73.3% of the patients harboured the same strains of C. albicans in the gastrointestinal tract as in the vagina.
由白色念珠菌引起的慢性外阴阴道炎是医生面临的一个主要临床问题。尽管现在有了新的抗真菌药物，但这种疾病的治疗方法仍然令人失望。本研究有两个目的。第一，我们想评估大多数临床医生进行的单次采样在验证酵母菌是否感染整个生殖黏膜或特定部位方面的可靠性；第二，对分离出的菌株进行生物分型，以确定是否有不止一种菌株导致感染。我们发现，在18例阴道念珠菌病患者中，整个生殖黏膜均被酵母菌感染，且在同一患者不同生殖部位分离出的菌株在100%的病例中是相同的。只有1.4%的样本为阴性。此外，我们对从这些患者胃肠道分离出的菌株进行生物分型，以评估该部位作为潜在感染源的可能性。我们从18例患者中的15例获取了胃肠道样本，且在100%的病例中都鉴定出了白色念珠菌。此外，73.3%的患者胃肠道中的白色念珠菌菌株与阴道中的相同。
