Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada.
J Hypertens. 2011 Oct;29(10):1871-9. doi: 10.1097/HJH.0b013e32834ae396.
We assessed the association between birth weight, weight change, and current blood pressure (BP) across the entire age-span of childhood and adolescence in large school-based cohorts in the Seychelles, an island state in the African region.
Three cohorts were analyzed: 1004 children examined at age 5.5 and 9.1 years, 1886 children at 9.1 and 12.5, and 1575 children at 12.5 and 15.5, respectively. Birth and 1-year anthropometric data were gathered from medical files. The outcome was BP at age 5.5, 9.1, 12.5 or 15.5 years, respectively. Conditional linear regression analysis was used to estimate the relative contribution of changes in weight (expressed in z-score) during different age periods on BP. All analyses were adjusted for height.
At all ages, current BP was strongly associated with current weight. Birth weight was not significantly associated with current BP. Upon adjustment for current weight, the association between birth weight and current BP tended to become negative. Conditional linear regression analyses indicated that changes in weight during successive age periods since birth contributed substantially to current BP at all ages. The strength of the association between weight change and current BP increased throughout successive age periods.
Weight changes during any age period since birth have substantial impact on BP during childhood and adolescence, with BP being more responsive to recent than earlier weight changes.
我们评估了塞舌尔大型学校队列中整个儿童期和青春期的出生体重、体重变化与当前血压（BP）之间的关系，塞舌尔是非洲地区的一个岛国。
分析了 3 个队列：1004 名儿童分别在 5.5 岁和 9.1 岁、1886 名儿童在 9.1 岁和 12.5 岁、1575 名儿童在 12.5 岁和 15.5 岁时进行检查。从医疗档案中收集出生和 1 岁时的人体测量数据。结果为分别在 5.5 岁、9.1 岁、12.5 岁或 15.5 岁时的 BP。使用条件线性回归分析来估计不同年龄期间体重变化（以 z 分数表示）对 BP 的相对贡献。所有分析均根据身高进行调整。
在所有年龄段，当前 BP 与当前体重密切相关。出生体重与当前 BP 无显著相关性。在校正当前体重后，出生体重与当前 BP 之间的关联趋于负相关。条件线性回归分析表明，自出生以来连续各年龄期间体重的变化对所有年龄段的当前 BP 有很大影响。体重变化与当前 BP 之间的关联强度随着连续各年龄期间的变化而增加。
自出生以来任何年龄期间的体重变化都会对儿童期和青春期的 BP 产生重大影响，BP 对近期体重变化比早期体重变化更为敏感。
