Department of Life Sciences, Faculty of Sciences and Technology, and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
Chem Commun (Camb). 2011 Oct 14;47(38):10635-7. doi: 10.1039/c1cc14019a. Epub 2011 Sep 1.
This communication demonstrates that yeast cell wall particles (YCWPs) are a promising class of nature-inspired biocompatible microcarriers for the delivery of amphipathic/lipophilic imaging reporters. When a paramagnetic MRI agent is loaded, the longitudinal relaxivity per particle at 0.5 T is the highest ever reported for Gd-based systems.
本研究表明酵母细胞壁颗粒（YCWPs）是一类很有前途的、受自然启发的、生物相容性的微载体，可用于递呈两亲性/亲脂性的成像报告分子。当负载顺磁性 MRI 造影剂时，在 0.5T 下每颗粒的纵向弛豫率比以往报道的基于 Gd 的系统都要高。
