Emmi L, Bertoni M, Iorno M L, Rossi O
Cattedra di Allergologia e Immunologia Clinica, Università degli Studi di Firenze.
Minerva Med. 1990 Apr;81(4):241-8.
The latest discoveries about the pathogenesis of asthma are reported with emphasis on new data concerning the discovery of factors capable of controlling the production of IgE antibodies. The mechanisms implicated in early and late phase reactions are then discussed. In addition, the relationships between neuropeptides and chronic inflammation are described. Finally, the role of active substances produced by the bronchial epithelium on the induction and maintenance of bronchial inflammation is reviewed.
报告了关于哮喘发病机制的最新发现,重点是有关能够控制IgE抗体产生的因素发现的新数据。接着讨论了早期和晚期反应所涉及的机制。此外,还描述了神经肽与慢性炎症之间的关系。最后,综述了支气管上皮产生的活性物质在诱导和维持支气管炎症中的作用。