Department of Neurology, Health Science Faculty, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland.
J Neural Transm (Vienna). 2012 Mar;119(3):363-7. doi: 10.1007/s00702-011-0707-5. Epub 2011 Sep 1.
The aim of the present study was to assess the origin of the substantia nigra hyperechogenicity in Parkinson disease patients. The cause of hyperechogenicity was tested on an animal model. Fresh porcine brains were injected consecutively with ferritin, apoferritin and water. Then, glioma samples were inserted into animal model. The echogenicity of the region of interest was assessed before and after experimental procedures. We observed the same echogenicity of porcine brain before and after injections of iron-loaded ferritin, apoferritin and water. Increased echogenicity of glioma samples compared to surrounding porcine brain tissue could be clearly seen. We postulate that the relative gliosis might be, at least partially, responsible for the increased echogenicity of the substantia nigra in Parkinson disease patients. Keeping in mind all limitations and inaccuracies of animal model used, it seems that hyperechogenicity of substantia nigra is caused rather by structural changes within the brain tissue than by increased iron concentration.
本研究旨在评估帕金森病患者黑质高回声的起源。在动物模型上测试了高回声的原因。新鲜猪脑连续注射铁蛋白、脱铁蛋白和水。然后，将神经胶质瘤样本插入动物模型。在实验前后评估感兴趣区域的回声。我们观察到铁蛋白、脱铁蛋白和水负载后猪脑的回声相同。与周围猪脑组织相比，神经胶质瘤样本的回声增加可以清晰地看到。我们推测，相对神经胶质增生至少部分是帕金森病患者黑质回声增加的原因。考虑到使用的动物模型的所有限制和不准确性，黑质回声增加似乎是由脑组织内的结构变化引起的，而不是由铁浓度增加引起的。
