[Changes of MMP-9 and TIMP-1 levels in gingival crevicular fluid during orthodontic tooth movement under orthodontic forces].

AIM

To investigate the dynamic changes of MMP-9 and TIMP-1 levels in gingival crevicular fluid during orthodontic tooth movement under orthodontic forces.

METHODS

select 20 cases which fit experiment condition. The cases divided randomly into 2 groups, 1- cases for each group. The distal forces of 100g and 250 g were exerted to the canine on the one side of two groups separately. The GCF were taken before activation and at 1, 2, 3, 4, 5, 6, 7 week respectively after initiation of the experiment. The levels of MMP-9 and TIMP-1 in GCF were determined by ELISA.

RESULTS

The levels of MMP-9 in A group began to increase at 1 week and reached to its peak value at 3 week after initiation of the experiment, but the level returned to baseline at 7 week. The levels of TIMP-1 in A group began to increase at 1, 2, 3 week and decreased at 4 week after initiation of the experiment, but the level at 6,7 week was higher than that before initiation of the experiment. The level of MMP-9 in A group was higher than that in B group at all times and the level of TIMP-1 in A group was lower than that in B group.

CONCLUSION

The level of MMP-9 and TIMP-1 in GCF may play an importance role in maintaining the health, the regular remodeling of the periodontium and the fast-moving of orthodontic tooth.