Faculty of Agriculture Research Park (FARP) and Biochemistry Department, Faculty of Agriculture, Cairo University, Giza, Egypt.
J Enzyme Inhib Med Chem. 2012 Oct;27(5):673-9. doi: 10.3109/14756366.2011.607446. Epub 2011 Sep 2.
Mevinolin (MVN) has been used clinically for the treatment of hypercholesterolemia with very good tolerance by patients. Based on epidemiological evidences, MVN was suggested strongly for the treatment of neoplasia. Early experimental trials suggested the mixed apoptotic/necrotic cell death pathway was activated in response to MVN exposure. Herein, the cytotoxic profile of MVN was evaluated, compared to the robust and frequently used anti-cancer drug doxorubicin (DOX), against breast (MCF-7), cervical (HeLa) and liver (HepG(2)) transformed cell lines. MVN was showed comparable results in cytotoxic profile with DOX in all tested solid tumor cell lines. In addition, the MVN-induced cytotoxicity was inferred to be multi-factorial and not solely dependent on p53 expression. It was concluded that molecular and genetic assessment of MVN-induced cell death would be useful for developing cancer therapeutic treatments.
美伐他汀（MVN）在临床上用于治疗高胆固醇血症，患者耐受性非常好。基于流行病学证据，MVN 强烈建议用于治疗肿瘤。早期实验试验表明，混合凋亡/坏死细胞死亡途径在 MVN 暴露时被激活。在此，评估了 MVN 的细胞毒性特征，并与常用的抗癌药物阿霉素（DOX）进行了比较，针对乳腺（MCF-7）、宫颈（HeLa）和肝脏（HepG(2))转化细胞系。MVN 在所有测试的实体瘤细胞系中的细胞毒性特征与 DOX 相当。此外，MVN 诱导的细胞毒性是多因素的，不仅仅依赖于 p53 表达。因此，MVN 诱导的细胞死亡的分子和遗传评估将有助于开发癌症治疗方法。
