Department of Neurology, Clinical University Hospital Lozano Blesa, Zaragoza, Spain.
Headache. 2011 Oct;51(9):1445-9. doi: 10.1111/j.1526-4610.2011.01991.x. Epub 2011 Aug 29.
It has been proposed that desaturation of oxygen during an apnea event is the trigger for cluster headache. Obstructive sleep apnea has been associated with a higher than normal cardiovascular morbidity and mortality. Some obstructive sleep apnea syndrome patients lack the sleep-related, nocturnal decrease, or "dip" in blood pressure, which is seen in normal individuals.
The aim of this study is to assess whether this non-dipper pattern is present in cluster headache patients.
A total of 30 normotensive cluster headache patients underwent an ambulatory blood pressure monitoring. "Non dippers" were defined as patients with a nighttime mean blood pressure fall <10%.
Fifteen cluster headache patients (50%) were non-dippers, a frequency higher than expected. The pattern of nocturnal non-dipping is associated with a higher body mass index. Non-dipper patients displayed higher mean nighttime systolic and diastolic blood pressure. No significant difference was observed in the mean 24-hour and daytime blood pressure.
The high incidence (50%) of non-dipper pattern in both processes, cluster headache and obstructive sleep apnea syndrome, provides support for the hypothesis of a relationship between theses 2 disorders.
有人提出，在呼吸暂停事件中氧气饱和度下降是丛集性头痛的触发因素。阻塞性睡眠呼吸暂停与高于正常的心血管发病率和死亡率有关。一些阻塞性睡眠呼吸暂停综合征患者缺乏正常个体夜间睡眠相关的血压下降，即“夜间下降”或“下降”。
本研究旨在评估丛集性头痛患者是否存在这种非杓型模式。
共 30 例血压正常的丛集性头痛患者接受了动态血压监测。“非杓型”定义为夜间平均血压下降<10%的患者。
15 例丛集性头痛患者（50%）为非杓型，这一频率高于预期。夜间非杓型的模式与较高的体重指数有关。非杓型患者夜间平均收缩压和舒张压较高。24 小时和白天的平均血压无显著差异。
在丛集性头痛和阻塞性睡眠呼吸暂停综合征这两种疾病中，非杓型模式的高发率（50%）为这两种疾病之间存在相关性提供了支持。
