Bühler C, Schaub A F, Vetter W
Departement für Innere Medizin, Universitätsspital Zürich.
Praxis (Bern 1994). 1994 Nov 8;83(45):1250-3.
Alterations in circadian blood pressure rhythm have been described in patients with sleep apnea syndrome or arterial hypertension. Epidemiologic data indicate an association of circadian blood pressure rhythm and obstructive snoring; however, only little is known about effects of apneic phases during sleep on arterial hypertension and their relevance for management of hypertension. Effects of arterial desaturation phases caused by apnea or hypopnea during sleep on arterial blood pressure have been investigated in altogether 16 probands. Thereby, a significant reduction of circadian blood pressure rhythm (p < 0.003) and of the difference between daily and nocturnal diastolic blood pressure values (p < 0.002) was found with increasing apnea index. Our results show that the sleep apnea syndrome or obstructive snoring, respectively, should be integrated more often in diagnostic and therapeutic management of arterial hypertension, especially when the circadian blood pressure rhythm appears to be levelled by ambulatory 24-hour monitoring of blood pressure values.
睡眠呼吸暂停综合征或动脉高血压患者存在昼夜血压节律改变。流行病学数据表明昼夜血压节律与阻塞性打鼾有关;然而,关于睡眠期间呼吸暂停阶段对动脉高血压的影响及其与高血压管理的相关性,人们知之甚少。总共对16名受试者研究了睡眠期间呼吸暂停或呼吸不足引起的动脉血氧饱和度降低阶段对动脉血压的影响。结果发现,随着呼吸暂停指数增加,昼夜血压节律显著降低(p<0.003),日间和夜间舒张压值之差也显著降低(p<0.002)。我们的结果表明,睡眠呼吸暂停综合征或阻塞性打鼾应更频繁地纳入动脉高血压的诊断和治疗管理中,尤其是当通过24小时动态血压监测发现昼夜血压节律趋于平稳时。