Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Clin Exp Dermatol. 2011 Oct;36(7):788-92. doi: 10.1111/j.1365-2230.2011.04118.x. Epub 2011 Aug 25.
Distinguishing keratoacanthoma (KA) from well-differentiated squamous cell carcinoma (SCC) is sometimes difficult. Recent evidence indicates that the nuclear factor kappa B p50 subunit (p50) and cortactin might be useful to distinguish between these two conditions.
To verify whether p50 and cortactin are useful differentiation markers to distinguish between subungual KA and well-differentiated SCC.
Immunohistochemistry using p50, cortactin and Ki-67 was performed on 20 patients with KA and 20 patients with facial well-differentiated SC. Ki-67 staining was also evaluated and scored.
Both p50 and cortactin had higher levels of expression in KA than in SCC. Both were localized to the basal-cell layer of KA, whereas they were scattered without polarity throughout the SCC lesions. Although the Ki-67 index was not significantly different between KA and SCC, the staining pattern also showed loss of polarity in SCC.
p50 and cortactin might be useful makers to distinguish between KA and well-differentiated SCC.
区分角化棘皮瘤（KA）和分化良好的鳞状细胞癌（SCC）有时较为困难。最近的证据表明，核因子κB p50 亚基（p50）和皮质肌动蛋白可能有助于区分这两种情况。
验证 p50 和皮质肌动蛋白是否可作为区分甲下 KA 和分化良好 SCC 的有用分化标志物。
对 20 例 KA 患者和 20 例面部分化良好 SCC 患者进行 p50、皮质肌动蛋白和 Ki-67 的免疫组织化学检测。还评估和评分了 Ki-67 染色。
p50 和皮质肌动蛋白在 KA 中的表达水平均高于 SCC。p50 和皮质肌动蛋白均定位于 KA 的基底层，而 SCC 病变中的染色则呈散在分布，无极性。尽管 KA 和 SCC 之间的 Ki-67 指数无显著差异，但染色模式也显示 SCC 极性丧失。
p50 和皮质肌动蛋白可能是区分 KA 和分化良好 SCC 的有用标志物。
