Department of Microbiology, Faculty of Medicine, Kuwait University.
Clin Microbiol Infect. 2011 Oct;17(10):1549-53. doi: 10.1111/j.1469-0691.2011.03608.x. Epub 2011 Aug 29.
This study determined the value of (1,3)-β-d-glucan (BDG), Candida mannan (MN) and Candida species-specific DNA as surrogates for diagnosis of candidaemia. Thirty-nine patients yielding Candida species in blood cultures were investigated for presence of BDG, MN and Candida species-specific DNA in serum samples. The Candida spp. bloodstream isolates included C. albicans (n = 16), C. tropicalis (n = 10), C. parapsilosis (n = 7), C. glabrata (n = 3) and C. dubliniensis (n = 3). Positivity of the three markers was as follows: Candida DNA for corresponding Candida species, 100%; BDG, 87%; MN, 59%. Despite varying sensitivities of these biomarkers, they provided a useful adjunct to the diagnosis of candidaemia.
本研究旨在确定(1,3)-β-D-葡聚糖（BDG）、甘露聚糖（MN）和念珠菌种特异性 DNA 作为念珠菌血症诊断替代物的价值。对 39 例血液培养出念珠菌的患者进行了血清样本中 BDG、MN 和念珠菌种特异性 DNA 的检测。念珠菌 spp.血流分离株包括白念珠菌（n = 16）、热带念珠菌（n = 10）、近平滑念珠菌（n = 7）、光滑念珠菌（n = 3）和都柏林念珠菌（n = 3）。三种标志物的阳性率如下：与相应念珠菌属的念珠菌 DNA，100%；BDG，87%；MN，59%。尽管这些生物标志物的敏感性不同，但它们为念珠菌血症的诊断提供了有用的辅助手段。
