UMR7242, University of Strasbourg-CNRS, ESBS, Blvd Sébastien Brant, F-67413 Illkirch, Strasbourg, France.
Environ Microbiol. 2011 Nov;13(11):2844-54. doi: 10.1111/j.1462-2920.2011.02556.x. Epub 2011 Aug 30.
Siderophores are chelators with extremely strong affinity for ferric iron and are best known for their capacity to feed microorganisms with this metal. Despite their preference for iron, they can also chelate numerous other metals with variable affinities. There is also increasing evidence that metals other than iron can activate the production of siderophores by bacteria, thereby implicating siderophores in the homeostasis of metals other than iron and especially heavy metal tolerance. This article considers this new concept that siderophores play a role in protecting bacteria against metal toxicity and discusses the possible contribution of these chelators to the transport of biological relevant metals in addition to iron.
铁载体是对三价铁具有极强亲和力的螯合剂，其最主要的功能是为微生物提供这种金属。尽管它们优先与铁结合，但也可以与其他多种金属结合，亲和力各不相同。越来越多的证据表明，除铁以外的金属也可以激活细菌产生铁载体，从而表明铁载体在除铁以外的金属，尤其是重金属耐受中的动态平衡中发挥作用。本文考虑了铁载体在保护细菌免受金属毒性方面发挥作用的新概念，并讨论了这些螯合剂除了铁以外，对生物相关金属运输的可能贡献。
