Life Science Programme, Centre for Biological Sciences, Central University of South Bihar, Patna 800014, India.
Life Science Programme, Centre for Biological Sciences, Central University of South Bihar, Patna 800014, India.
Microbiol Res. 2018 Jul-Aug;212-213:103-111. doi: 10.1016/j.micres.2017.10.012. Epub 2017 Nov 2.
Siderophores, the secondary metabolite of various microorganisms are ferric ion specific chelators secreted under iron stressed condition. These non-ribosomal peptides have been classified as catecholate, hydroxamate, carboxylate and mixed types. Recent studies focus on discovery of possible mammalian siderophores. The biosynthesis pathway including non-ribosomal dependent as well as non-ribosomal independent pathways are of great interest now a days. Many significant roles of siderophores such as virulence in pathogens, oxidative stress tolerance, classification of organisms etc. are being discovered. Studies on siderophore utilization in bioremediation and other heavy metal chelation have increased in past decade. The iron chelation ability of siderophores is being recently studied with regards to malignant cancerous cells. Not only this, it has been found that they possess antimicrobial properties which can be utilized against number of microbes. This review covers all recent aspects of siderophore and its applications.
铁载体是各种微生物的次生代谢产物，是在铁胁迫条件下分泌的铁离子特异性螯合剂。这些非核糖体肽已被分类为儿茶酚、羟肟酸、羧酸盐和混合类型。最近的研究集中在发现可能的哺乳动物铁载体上。目前，人们对生物合成途径（包括非核糖体依赖性和非核糖体独立性途径）非常感兴趣。铁载体具有许多重要作用，如病原体的毒力、氧化应激耐受、生物分类等。在过去十年中，铁载体在生物修复和其他重金属螯合中的利用研究有所增加。最近，人们研究了铁载体对恶性癌细胞的铁螯合能力。不仅如此，还发现它们具有抗菌特性，可用于对抗多种微生物。本综述涵盖了铁载体及其应用的所有最新方面。
