Departments of Medical Genetics, University Medical Centre Utrecht, The Netherlands.
BJU Int. 2012 Apr;109(8):1243-8. doi: 10.1111/j.1464-410X.2011.10469.x. Epub 2011 Aug 24.
To assess whether there is an increased prevalence of joint hypermobility in patients with vesico-ureteric reflux (VUR).
We studied 50 patients with primary VUR and matched controls drawn from a reference population. Joint mobility was assessed using the Bulbena hypermobility score.
We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).
Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre-existing) VUR phenotype.
评估膀胱输尿管反流（VUR）患者是否存在关节过度活动症的发病率增加。
我们研究了 50 例原发性 VUR 患者和从参考人群中匹配的对照组。使用 Bulbena 关节活动过度评分评估关节活动度。
我们发现 VUR 患者的全身性关节过度活动症明显多于对照组（24% vs 6.7%，P=0.007）。
我们的研究结果证实了我们的临床观察，即 VUR 患者的关节过度活动症发病率增加。我们推测，结缔组织的组成改变可能导致（已存在的）VUR 表型的严重程度增加。
