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成功实现脑死亡供者器官捐献:中国器官移植中心的经验。

Successful organ donation from brain dead donors in a Chinese organ transplantation center.

机构信息

Kidney Transplantation and HemoPurification Center, 181st Hospital, Guilin, Guangxi, People's Republic of China.

出版信息

Am J Transplant. 2011 Oct;11(10):2247-9. doi: 10.1111/j.1600-6143.2011.03694.x. Epub 2011 Aug 22.

DOI:10.1111/j.1600-6143.2011.03694.x
PMID:21883900
Abstract

Solid organ transplantation is an effective treatment for patients with end-stage organ failure. Donation after brain death (DBD) is a means of addressing the inadequate supply of acceptable donor organs but has only gradually begun to be accepted in mainland China. A major barrier has been the absence of brain death and organ transplant legislation. This paper describes our initial experience with organ transplantation using organs from brain dead donors and discusses strategies for encouraging organ transplantation and brain death legislation in China. Six patients underwent renal transplantation and two patients underwent liver transplantation with organs procured from three brain dead donors at the Organ Transplantation Center, the 181st Hospital. All patients are alive with excellent graft function. DBD is an important means of increasing the number of organs available for transplantation and its widespread implementation in China should be encouraged. Brain death and organ transplantation legislation is necessary to ensure the rights and obligations of donors, recipients and medical institutions.

摘要

器官移植是治疗终末期器官衰竭患者的有效方法。脑死亡后捐献(DBD)是解决可接受供体器官供应不足的一种手段,但在中国内地仅逐渐开始被接受。主要障碍是缺乏脑死亡和器官移植立法。本文描述了我们使用脑死亡供体器官进行器官移植的初步经验,并讨论了在中国鼓励器官移植和脑死亡立法的策略。器官移植中心、181 医院共进行了 6 例肾移植和 2 例肝移植,使用了 3 例脑死亡供者的器官。所有患者均存活,移植物功能良好。DBD 是增加可供移植器官数量的重要手段,应在中国广泛推广。脑死亡和器官移植立法是确保供者、受者和医疗机构权利和义务的必要条件。

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引用本文的文献

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Posttransplant Outcomes of Kidneys Donated After Brain Death Followed by Circulatory Death: A Cohort Study of 128 Chinese Patients.脑死亡后循环死亡器官捐献肾移植受者的预后:128例中国患者的队列研究
Transplant Direct. 2017 Jul 5;3(8):e189. doi: 10.1097/TXD.0000000000000704. eCollection 2017 Aug.
2
Proteomic analysis of differentially expressed proteins in kidneys of brain dead rabbits.脑死亡兔肾脏中差异表达蛋白质的蛋白质组学分析
Mol Med Rep. 2017 Jul;16(1):215-223. doi: 10.3892/mmr.2017.6609. Epub 2017 May 19.
3
Brain death declaration: Practices and perceptions worldwide.
脑死亡判定:全球范围内的实践与认知
Neurology. 2015 May 5;84(18):1870-9. doi: 10.1212/WNL.0000000000001540. Epub 2015 Apr 8.
4
The Declaration of Istanbul--early impact and future potential.《伊斯坦布尔宣言》——早期影响与未来潜力。
Nat Rev Nephrol. 2012 Mar 20;8(6):358-61. doi: 10.1038/nrneph.2012.59.