Mayo Clinic College of Medicine, Center for Translational Science Activities, Rochester, Minnesota, USA.
Clin Transl Sci. 2011 Aug;4(4):279-81. doi: 10.1111/j.1752-8062.2011.00297.x.
The journey of gene transfer from laboratory to clinic has been slow and fraught with many challenges and barriers. Despite the development of the initial technology in the early 1970s, a standard clinical treatment involving "gene therapy" remains to be seen. Furthermore, much was written about the technology in the early 1990s, but since then, not much has been written about the journey of gene transfer. The translational path of gene transfer thus far, both pitfalls and successes, can serve as a study not only in navigating ethical and safety concerns, but also in the importance of scientist-public interactions. Here, we examine the translational progress of gene transfer and what can be gleaned from its history.
从实验室到临床，基因转移的过程缓慢而充满挑战和障碍。尽管这项技术在 20 世纪 70 年代初就有了初步的发展，但涉及“基因治疗”的标准临床治疗方法仍有待观察。此外，早在 20 世纪 90 年代就有很多关于这项技术的报道，但此后，关于基因转移过程的报道并不多。迄今为止，基因转移的转化途径，包括陷阱和成功，可以作为一项研究，不仅探讨了伦理和安全问题，还探讨了科学家与公众互动的重要性。在这里，我们研究了基因转移的转化进展以及可以从其历史中获得的启示。
