Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Alfredo Balena, 190, Belo Horizonte, CEP 30130-100, Brazil.
Peptides. 2011 Sep;32(9):1787-92. doi: 10.1016/j.peptides.2011.08.013. Epub 2011 Aug 22.
B-type natriuretic peptide (BNP) is a diagnostic and prognostic tool in heart failure and also in Chagas disease, which is caused by the protozoan Trypanosoma cruzi and has cardiomyopathy as a main feature. BNP lipolytic actions and T. cruzi infection in the adipose tissue have been recently described. We aim to investigate the relationship between BNP and anthropometric measures and whether it is influenced by T. cruzi infection. We measured BNP, body mass index (BMI), waist circumference (WC), triceps skin-fold thickness (TSF) and performed serological, biochemical and electrocardiographic exams in 1398 subjects (37.5% infected with T. cruzi) in a community-dwelling elderly population in Bambui city, Brazil. Linear multivariate regression analysis was performed to investigate determinants of BNP levels. BNP levels were significantly (p<0.05) higher in T. cruzi-infected subjects than in the non-infected group (median=121 and 64pg/mL, respectively). BMI, WC and TSF in infected subjects were significantly lower than those in non-infected subjects (24.3 vs. 25.5kg/m2; 89.2 vs. 92.4cm; and 14.5 vs. 16.0mm, respectively). There was an inverse relationship between BNP levels and BMI (b=-0.018), WC (b=-0.005) and TSF (b=-0.193) levels. Infected and non-infected groups showed similar inverse relationships between BNP and BMI (b=-0.021 and b=-0.015, respectively). In conclusion, there was an inverse relationship between BNP levels and the anthropometric measures. Despite the actions in the adipose tissue, T. cruzi infection did not modify the associations between BNP and BMI, suggesting that body mass does not modify the accuracy of BNP in Chagas disease.
B 型利钠肽（BNP）是心力衰竭和恰加斯病（一种由原生动物克氏锥虫引起的疾病，以心肌病为主要特征）的诊断和预后工具。最近描述了 BNP 的脂解作用和 T. cruzi 在脂肪组织中的感染。我们旨在研究 BNP 与人体测量学指标之间的关系，以及它是否受 T. cruzi 感染的影响。我们在巴西 Bambui 市的一个社区居住的老年人群中测量了 1398 名受试者（37.5%感染了 T. cruzi）的 BNP、体重指数（BMI）、腰围（WC）、肱三头肌皮褶厚度（TSF），并进行了血清学、生化和心电图检查。进行了线性多元回归分析以研究 BNP 水平的决定因素。与未感染组相比，感染 T. cruzi 的受试者的 BNP 水平显着升高（p<0.05）（中位数分别为 121 和 64pg/mL）。感染组的 BMI、WC 和 TSF 显着低于未感染组（24.3 与 25.5kg/m2；89.2 与 92.4cm；14.5 与 16.0mm）。BNP 水平与 BMI（b=-0.018）、WC（b=-0.005）和 TSF（b=-0.193）水平呈负相关。感染组和未感染组的 BNP 与 BMI 之间呈相似的负相关关系（b=-0.021 和 b=-0.015）。总之，BNP 水平与人体测量学指标之间呈负相关。尽管 T. cruzi 感染在脂肪组织中具有作用，但它并没有改变 BNP 与 BMI 之间的关联，这表明体重不会改变 BNP 在恰加斯病中的准确性。
