一种新的 FOXO 信号通路与白血病发生相关。
A new FOXO pathway required for leukemogenesis.
机构信息
Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
出版信息
Cell. 2011 Sep 2;146(5):669-70. doi: 10.1016/j.cell.2011.08.019.
PMID:21884926
Abstract
In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.
摘要
在癌症中，FOXO 转录因子家族作为肿瘤抑制因子发挥作用，并且通过 PI3K/AKT 途径被致癌信号直接失活。现在，Skykes 等人（2011）确定了 FOXO 在维持白血病起始细胞中的一个矛盾的需求。
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