Grand A, Glaizal S, Caudie C, Schrive I, Matas O, Fichter P, Shibli H
Service de Cardiologie, Centre Hospitalier, Valence.
Ann Cardiol Angeiol (Paris). 1990 Mar;39(3):137-42.
The serum myoglobin (MG) was assayed by the radio-immunological method in 30 patients, all victims of a recent myocardial infarction (MI) and in 30 tests subjects suffering (21 cases) or not (9 cases) from heart diseases, but none from myocardial infarction (MI). The blood samples have been collected on hospital admission of the patient, then every four hours during the first 48 hours and finally, every 12 hours from the 48th to 72nd hour. The normal value is less than 85 micrograms/l. The creatine-kinase (CK), the aspartate aminotransferase (ASAT), the alanine aminotransferase (ALAT) and the lactate dehydrogenase (LDH) were also assayed each time. In MI, there is a significant increase in the serum MG level (731 +/- 323 micrograms/l against 174 +/- 198 micrograms/l in the test subjects; p less than 0.001). The sensitivity of this assay reaches 97%, its specificity 80%, its positive predictive value 83% and its negative predictive value 96%. Starting from the beginning of the characteristic pain of infarction, the MG level exceeds the normal values after 3.3 +/- 1.6 hours, reaches its maximum after 9.3 +/- 3.7 hours and comes back to normal after 38 +/- 8.1 hours. On the other hand, the MG level does not enable any conclusion regarding either the transmural/not transmural nature, or the site, or the acuteness of the MI.(ABSTRACT TRUNCATED AT 250 WORDS)
采用放射免疫法对30例近期心肌梗死（MI）患者及30例患有（21例）或未患（9例）心脏病但无心肌梗死的受试对象测定血清肌红蛋白（MG）。患者入院时采集血样，随后在最初48小时内每4小时采集一次，最后从48小时至72小时每12小时采集一次。正常值低于85微克/升。每次还测定肌酸激酶（CK）、天冬氨酸转氨酶（ASAT）、丙氨酸转氨酶（ALAT）和乳酸脱氢酶（LDH）。在心肌梗死患者中，血清MG水平显著升高（731±323微克/升，而受试对象为174±198微克/升；p<0.001）。该检测方法的敏感性达97%，特异性80%，阳性预测值83%，阴性预测值96%。从梗死特征性疼痛开始，MG水平在3.3±1.6小时后超过正常值，在9.3±3.7小时后达到峰值，38±8.1小时后恢复正常。另一方面，MG水平无法对心肌梗死的透壁/非透壁性质、部位或急性程度得出任何结论。（摘要截短于250字）
