Confocal imaging studies cast doubt on nuclear localization of JAK2V617F.
作者信息
Girodon François, Steinkamp Mara P, Cleyrat Cédric, Hermouet Sylvie, Wilson Bridget S
出版信息
Blood. 2011 Sep 1;118(9):2633-4. doi: 10.1182/blood-2011-02-336479.
Abstract
摘要
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本文引用的文献
1
Preferential nuclear accumulation of JAK2V617F in CD34+ but not in granulocytic, megakaryocytic, or erythroid cells of patients with Philadelphia-negative myeloproliferative neoplasia.在费城染色体阴性骨髓增殖性肿瘤患者的 CD34+细胞中，JAK2V617F 优先发生核积累，而在粒细胞、巨核细胞或红细胞中则不然。
Blood. 2010 Dec 23;116(26):6023-6. doi: 10.1182/blood-2010-08-302265. Epub 2010 Sep 22.
2
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.JAK2使组蛋白H3Y41磷酸化，并将HP1α排除在染色质之外。
Nature. 2009 Oct 8;461(7265):819-22. doi: 10.1038/nature08448. Epub 2009 Sep 27.
3
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.一种导致持续性信号传导的独特克隆性JAK2突变会引发真性红细胞增多症。
Nature. 2005 Apr 28;434(7037):1144-8. doi: 10.1038/nature03546.
4
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