Bethea M, Forman D T
Division of Clinical Chemistry, North Carolina Memorial Hospital, University of North Carolina, Chapel Hill 27599.
Ann Clin Lab Sci. 1990 May-Jun;20(3):163-8.
beta 2-Microglobulin (beta 2M), an interesting and underutilized metabolite, can be used in assessing renal function, particularly in kidney-transplant recipients and in patients suspected of having renal tubulointerstitial disease. It also can serve as a nonspecific but relatively sensitive marker of various neoplastic, inflammatory, and infectious conditions. Early hopes that it would be a useful serum test for malignancy have not been fulfilled, but it does have prognostic value for patients with lymphoproliferative disease, particularly multiple myeloma. More recent reports have suggested a role for beta 2M as a prognostic marker in human immunodeficiency virus (HIV) infection.
β2微球蛋白（β2M）是一种有趣但未得到充分利用的代谢产物，可用于评估肾功能，特别是在肾移植受者和疑似患有肾小管间质性疾病的患者中。它还可作为各种肿瘤、炎症和感染性疾病的非特异性但相对敏感的标志物。早期曾希望它能成为一种有用的恶性肿瘤血清检测指标，但这一希望并未实现，不过它对淋巴增殖性疾病患者，尤其是多发性骨髓瘤患者具有预后价值。最近的报告表明，β2M在人类免疫缺陷病毒（HIV）感染中可作为一种预后标志物。
