Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
AJNR Am J Neuroradiol. 2012 Feb;33(2):376-81. doi: 10.3174/ajnr.A2618. Epub 2011 Sep 1.
Most physicians consider length of preoperative pain as an important factor to include patients for SA. Our aim was to synthesize the available evidence regarding the influence of preprocedural pain duration on the outcome of vertebral augmentation procedures.
The MEDLINE data base was reviewed up to March 2010. Meta-regression and mixed-effect subgroup analyses were performed to evaluate the association between the outcome of interest, which was pain improvement assessed by a VAS (0-10) and the duration of preoperative pain (independent variable).
We included 17 articles. The mean VAS improvements for subgroups of ≤6 weeks (n = 12), 6-24 weeks (n = 5), and >24 weeks (n = 3) were 5.18, 4.90, and 5.04, respectively (P = .86). The regression coefficient was -0.024, suggesting trivial association of the duration of preoperative pain and pain improvement.
Pain relief following spine augmentation was similar among groups of patients with varying lengths of preoperative pain duration.
大多数医生认为术前疼痛的持续时间是选择患者进行脊柱强化术（SA）的一个重要因素。我们的目的是综合现有证据，评估术前疼痛持续时间对椎体强化术效果的影响。
对截至 2010 年 3 月的 MEDLINE 数据库进行了回顾。采用 Meta 回归和混合效应亚组分析，评估与研究目的相关的结果，即通过视觉模拟评分（VAS，0-10 分）评估的疼痛改善情况与术前疼痛持续时间（自变量）之间的关系。
我们共纳入 17 篇文章。术前疼痛持续时间≤6 周（n = 12）、6-24 周（n = 5）和＞24 周（n = 3）亚组的 VAS 改善均值分别为 5.18、4.90 和 5.04（P =.86）。回归系数为-0.024，表明术前疼痛持续时间与疼痛改善之间的关联微不足道。
术前疼痛持续时间不同的患者在接受脊柱强化术后的疼痛缓解程度相似。
