Division of Stroke and Critical Care, Department of Neurology, University of Southern California, 1510 San Pablo Street, HCC 643, Los Angeles, CA 90033, USA.
Stroke. 2011 Nov;42(11):3029-33. doi: 10.1161/STROKEAHA.111.618454. Epub 2011 Sep 1.
Little is known about sex-specific stroke hospitalization rates among middle-aged individuals. This study assessed recent temporal trends in stroke hospitalizations among persons aged 35 to 64 years in the United States.
The Nationwide Inpatient Sample was used to identify individuals with a primary or secondary discharge diagnosis of stroke between 1997 and 2006 (n=3,161,752). Age-adjusted sex-specific rates of ischemic and hemorrhagic stroke hospitalizations were assessed among individuals aged 35 to 64 years.
Over the study period, stroke hospitalization rates per 100 000 decreased by 10% from 66.7 to 60.3 (trend P<0.01) in men and 8% from 52.7 to 48.3 (trend P<0.001) in women. The 55- to 64-year age group drove reductions in hospitalization rates: slope (rate of change per year)=-12.3 for men and -8.9 for women (both P<0.001). Rates increased slightly in men and women aged 35 to 44 years and remained stable for persons aged 45 to 54 years. Stroke subtype analysis revealed that rates of ischemic stroke hospitalization increased and hemorrhagic stroke hospitalization remained stable among individuals aged 35 to 44 years. Rates of ischemic and hemorrhagic stroke hospitalizations remained stable among those aged 45 to 54 years and decreased among persons aged 55 to 64 years.
From 1997 to 2006, ischemic and hemorrhagic stroke hospitalization rates declined among individuals aged 55 to 64 years and remained stable among persons aged 45 to 54 years; ischemic stroke hospitalization rates increased among individuals aged 35 to 44 years. Further studies are needed to assess and address increases in ischemic stroke hospitalizations among younger individuals.
对于中年人群中特定性别卒中住院率的情况，我们知之甚少。本研究评估了美国 35 至 64 岁人群中卒中住院的近期时间趋势。
我们使用全国住院患者样本（1997 年至 2006 年），确定患有初次或二次卒中诊断的患者（n=3,161,752）。评估了 35 至 64 岁人群中缺血性和出血性卒中住院的年龄调整后性别特异性比率。
在研究期间，男性卒中住院率从 66.7 下降至 60.3（趋势 P<0.01），下降了 10%；女性卒中住院率从 52.7 下降至 48.3（趋势 P<0.001），下降了 8%。55 至 64 岁年龄组是导致住院率下降的主要因素：斜率（每年变化率）为-12.3（男性，P<0.001）和-8.9（女性，P<0.001）。35 至 44 岁年龄组的男性和女性卒中住院率略有增加，而 45 至 54 岁年龄组的住院率保持稳定。卒中亚型分析显示，35 至 44 岁人群中缺血性卒中住院率增加，出血性卒中住院率保持稳定。45 至 54 岁人群的缺血性和出血性卒中住院率保持稳定，而 55 至 64 岁人群的卒中住院率下降。
从 1997 年到 2006 年，55 至 64 岁人群的缺血性和出血性卒中住院率下降，而 45 至 54 岁人群的住院率保持稳定；35 至 44 岁人群的缺血性卒中住院率增加。需要进一步研究以评估和解决年轻人群中缺血性卒中住院率的增加。
