Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY 10003, USA.
Cornea. 2011 Nov;30(11):1267-9. doi: 10.1097/ICO.0b013e31820ca654.
To report 2 patients with progressive complex choristomas and to review the literature on this subject.
Interventional case reports.
Clinical and pathologic correlation was performed on 2 patients with progressive epibulbar choristomas. PubMed database was searched to identify all the previously reported cases of progressive epibulbar choristomas (using key words choristoma, dermoid, growth, progression, and evolution).
Growth of the epibulbar choristomas was noted in infancy in 1 patient with oculoectodermal syndrome and in puberty in another otherwise healthy patient. Both lesions were identified histopathologically as complex choristomas. In addition to the characteristic choristomatous tissues, both lesions demonstrated increased vascularity, inflammatory infiltrate, and fibroblast proliferation within myxomatous stroma. Review of the literature identified 4 patients with progressive complex choristomas, 1 of whom demonstrated histopathologic findings similar to those of the 2 cases reported here.
Epibulbar choristomas rarely enlarge, likely secondary to reactive changes within the tissue manifested by increased vascularity, inflammatory cell infiltration, and fibroblast proliferation with deposition of myxomatous stroma.
报告 2 例进行性复杂皮样瘤病例，并复习相关文献。
介入性病例报告。
对 2 例进行性眶皮样瘤患者进行临床和病理相关性分析。在 PubMed 数据库中，使用关键词“皮样瘤、表皮样囊肿、生长、进展和演变”，检索所有先前报道的进行性眶皮样瘤病例。
1 例眼外胚层综合征患者在婴儿期和另 1 例健康患者在青春期发现眶皮样瘤生长。2 例病变均经组织病理学检查诊断为复杂皮样瘤。除了特征性的皮样瘤组织外，2 例病变均表现为黏液样基质中血管增多、炎症浸润和纤维母细胞增生。文献复习发现 4 例进行性复杂皮样瘤患者，其中 1 例的组织病理学发现与本文报告的 2 例相似。
眶皮样瘤很少增大，可能是由于组织内的反应性变化所致，表现为血管增多、炎症细胞浸润和纤维母细胞增生，伴有黏液样基质沉积。
