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[心脏与糖尿病]

[The heart and diabetes mellitus].

作者信息

Lerman Garber I, Ahumada Ayala M, Posadas Romero C

机构信息

Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.E.

出版信息

Arch Inst Cardiol Mex. 1990 Jan-Feb;60(1):79-88.

PMID:2188626
Abstract

The atherosclerotic process in the diabetic patient, is more common, it is noticed at early ages, advances more rapidly and almost equally affects males and females. This data, can not be explained on the basis of the association with other coronary heart disease risk factors, there is an intrinsic atherogenic factor attributed to diabetes, and can be related, to the early hyperinsulinemia, coagulation and lipid disorders, hyperglycemia or diabetic microangiopathy. Coronary heart disease has an increased prevalence in diabetic patients, that is not related with diabetes duration or the type of treatment. Early and late morbimortality after acute myocardial infarction and/or revascularization surgery is twice as common in the diabetic patient. Diabetic cardiomyopathy related to small vessels disease is still a matter of controversy and many authors doubt about its relevance in clinical practice. The presence of autonomic neuropathy with the cardiovascular denervation syndrome carries a poor prognosis. Early cardiovascular changes in asymptomatic patients, are detected with non-invasive test, and can help to introduce measures to protect individuals at a greater risk.

摘要

糖尿病患者的动脉粥样硬化进程更为常见,在早年即可出现,进展更为迅速,且几乎同等程度地影响男性和女性。这些数据无法基于与其他冠心病危险因素的关联来解释,存在一种归因于糖尿病的内在致动脉粥样硬化因素,可能与早期高胰岛素血症、凝血及脂质紊乱、高血糖或糖尿病微血管病变有关。冠心病在糖尿病患者中的患病率增加,这与糖尿病病程或治疗类型无关。糖尿病患者急性心肌梗死和/或血运重建术后的早晚期病残率和死亡率是常人的两倍。与小血管疾病相关的糖尿病性心肌病仍存在争议,许多作者怀疑其在临床实践中的相关性。伴有心血管去神经支配综合征的自主神经病变预后不良。无症状患者的早期心血管变化可通过非侵入性检查检测到,有助于采取措施保护高危个体。

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