Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
Curr Neuropharmacol. 2011 Mar;9(1):151-4. doi: 10.2174/157015911795017119.
Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.
内皮型一氧化氮合酶（NOS3）是影响人类大脑中一氧化氮（NO）功能的酶之一。NO 是一种气体神经递质，参与中枢神经系统的多种机制，如 N-甲基-D-天冬氨酸受体激活和氧化应激。动物药理学研究和尸检研究的证据支持 NO 与精神病障碍之间存在关联。甲基苯丙胺（METH）使用障碍是一种已知的精神病障碍，因此我们在日本受试者中进行了 NOS3 中的标记单核苷酸多态性（SNP）（rs2070744、rs1799983）与 METH 诱导的精神病之间的基于基因的病例对照研究（183 例 METH 诱导的精神病和 267 例对照）。每位受试者均获得书面知情同意。在等位基因/基因型或单体型分析中，NOS3 中的任何标记 SNP 与 METH 诱导的精神病之间均未发现显著关联。总之，我们认为 NOS3 可能不会增加日本人发生 METH 诱导的精神病的风险。
