Gregory Larissa A, Ricart Rachel A, Patel Shyam A, Lim Philip K, Rameshwar Pranela
Department of Medicine - Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA.
Curr Cancer Ther Rev. 2011 Aug;7(3):176-183. doi: 10.2174/157339411796234915.
The failed outcome of autologous bone marrow transplantation for breast cancer opens the field for investigations. This is particularly important because the bone marrow could be a major source of cancer cells during tertiary metastasis. This review discusses subsets of breast cancer cells, including those that enter the bone marrow at an early period of disease development, perhaps prior to clinical detection. This population of cells evades chemotherapeutic damage even at high doses. An understanding of this population might be crucial for the success of bone marrow transplants for metastatic breast cancer and for the eradication of cancer cells in bone marrow. In vivo and in vitro studies have demonstrated gap junctional intercellular communication (GJIC) between bone marrow stroma and breast cancer cells. This review discusses GJIC in cancer metastasis, facilitating roles of mesenchymal stem cells (MSCs). In addition, the review addresses potential roles for miRNAs, including those already linked to cancer biology. The literature on MSCs is growing and their links to metastasis are beginning to be significant leads for the development of new drug targets for breast cancer. In summary, this review discusses interactions among GJIC, miRNAs and MSCs as future consideration for the development of cancer therapies.
自体骨髓移植治疗乳腺癌的失败结果为相关研究开辟了领域。这一点尤为重要，因为骨髓可能是肿瘤三级转移期间癌细胞的主要来源。本综述讨论了乳腺癌细胞的亚群，包括那些在疾病发展早期（可能在临床检测之前）进入骨髓的细胞。即使在高剂量化疗时，这群细胞也能逃避化疗损伤。了解这群细胞对于转移性乳腺癌骨髓移植的成功以及根除骨髓中的癌细胞可能至关重要。体内和体外研究均已证实骨髓基质与乳腺癌细胞之间存在间隙连接细胞间通讯（GJIC）。本综述讨论了GJIC在癌症转移中的作用、间充质干细胞（MSC）的促进作用。此外，本综述还探讨了微小RNA（miRNA）的潜在作用，包括那些已与癌症生物学相关联的miRNA。关于MSC的文献不断增加，它们与转移的联系正开始成为乳腺癌新药靶点开发的重要线索。总之，本综述讨论了GJIC、miRNA和MSC之间的相互作用，作为癌症治疗发展的未来考量因素。
