Institute of Biology, Bergen High Technology Center, University of Bergen Bergen, Norway.
Front Physiol. 2011 Jul 26;2:44. doi: 10.3389/fphys.2011.00044. eCollection 2011.
Aquaporins represent a primordial group of transmembrane solvent channels that have been documented throughout the living biota. This facet alone emphasizes the positive selection pressure for proteins associated with intracellular fluid homeostasis. Amongst extant Eukaryota the highest gene copy number can be found in plants and teleosts, a feature that reflects the genomic duplication history in both groups. In this minireview we discuss the discovery, structure, duplication, and diversification of the aquaporin superfamily. We focus on teleosts as the main models, but include data available for other organisms to provide a broader perspective.
水通道蛋白是跨膜溶剂通道的原始群组，在所有生物中都有记录。这一事实本身就强调了与细胞内液稳态相关的蛋白质所受到的正向选择压力。在现存的真核生物中，植物和硬骨鱼的基因拷贝数最高，这一特征反映了这两个群体的基因组重复历史。在这篇综述中，我们讨论了水通道蛋白超家族的发现、结构、复制和多样化。我们以硬骨鱼为主要模型，但也包括了其他生物体的数据，以提供更广泛的视角。
