The pancornulins: a group of basic low molecular weight proteins in mammalian epidermis and epithelium that may function as cornified envelope precursors.
作者信息
Phillips S B, Kubilus J, Grassi A M, Goldaber M L, Baden H P
机构信息
Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
出版信息
Comp Biochem Physiol B. 1990;95(4):781-8. doi: 10.1016/0305-0491(90)90317-m.
A monoclonal antibody (HCE-2) to human epidermal and epithelial cornified envelopes identified a group of soluble basic protein precursors. 2. Using HCE-2, envelope-like staining was observed in the epidermis and stratified squamous epithelium of a number of mammalian species. 3. Basic polypeptides reactive to HCE-2 varied in size and number among the different animals. 4. In those species studied, HCE-2-reactive peptides were substrates for transglutaminase and protease treatment of cornified envelopes released HCE-2-reactive degradation products. 5. These results suggest a new family of proteins in mammalian epidermis that may function as cornified envelope precursors.
