脂 A 装配途径：克里斯蒂安·雷茨的工作。
The lipid A assembly pathway: the work of Christian Raetz.
出版信息
J Biol Chem. 2011 Jul 22;286(29):e6-8. doi: 10.1074/jbc.o111.000247.
During his career, Christian Raetz has characterized many enzymes responsible for synthesizing or modifying lipid molecules, including the entire nine-enzyme pathway for the biosynthesis of lipid A, an essential part of bacterial outer membranes that plays a role in making many Gram-negative bacteria toxic. The findings from the two (JBC) Classic articles reprinted here were the start of Raetz' elucidation of the enzymology, genetics, and structural biology of lipid A assembly. Fatty Acyl Derivatives of Glucosamine 1-Phosphate in and Their Relation to Lipid A. Complete Structure of a Diacyl GlcN-1-P Found in a Phosphatidylglycerol-deficient Mutant (Takayama, K., Qureshi, N., Mascagni, P., Nashed, M. A., Anderson, L., and Raetz, C. R. H. (1983) 258, 7379–7385) The Biosynthesis of Gram-negative Endotoxin. Formation of Lipid A Precursors from UDP-GlcNAc in Extracts of (Anderson, M. S., Bulawa, C. E., and Raetz, C. R. H. (1985) 260, 15536–15541)
在他的职业生涯中，Christian Raetz 鉴定了许多负责合成或修饰脂质分子的酶，包括脂质 A 生物合成的完整九酶途径，脂质 A 是细菌外膜的重要组成部分，在使许多革兰氏阴性菌有毒性方面发挥作用。这里重新印刷的两篇 （JBC）经典文章中的发现是 Raetz 阐明脂质 A 组装的酶学、遗传学和结构生物学的起点。和中的葡萄糖胺 1-磷酸的脂肪酸衍生物及其与脂质 A 的关系（Takayama，K.，Qureshi，N.，Mascagni，P.，Nashed，M. A.，Anderson，L.，和 Raetz，C. R. H.（1983） 258, 7379–7385）革兰氏阴性内毒素的生物合成。从 UDP-GlcNAc 在 的提取物中形成脂 A 前体（Anderson，M. S.，Bulawa，C. E.，和 Raetz，C. R. H.（1985） 260, 15536–15541）
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