Prasad G B, Ramaprasad P, Rao V S, Bharati M S, Harinath B C
Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Wardha.
Indian J Med Res. 1990 Mar;91:133-7.
Two regimens of diethyl carbamazine (DEC) viz., 14 day and 5 day, were compared for microfilaricidal effect and side effects, in the treatment of bancroftian filariasis. The rate of successful treatment, cure rate and decrease in mf count were found to be significantly high with the 14 days regimen when assessed immediately after treatment. About 40 per cent of subjects on the 14 days regimen and 66 per cent of patients on 5 days regimen experienced side reactions. The severity of side reactions was more in patients on 5 days regimen. When the effect of DEC was assessed one year after treatment with the 14 days regimen and compared with the results immediately after treatment, the rate of successful treatment, cure rate and decrease in mf count were reduced significantly. The 14 days DEC regimen with initial low dose of DEC along with antipyretics may be better accepted in the control programmes of filariasis.
在治疗班氏丝虫病时，比较了两种乙胺嗪（DEC）治疗方案，即14天疗程和5天疗程，观察其杀微丝蚴效果和副作用。治疗后立即评估发现，14天疗程的成功治疗率、治愈率和微丝蚴计数下降率显著更高。14天疗程的约40%受试者和5天疗程的66%患者出现了副作用。5天疗程患者的副作用严重程度更高。在用14天疗程治疗一年后评估DEC的效果并与治疗后立即得到的结果进行比较时，成功治疗率、治愈率和微丝蚴计数下降率显著降低。在丝虫病控制项目中，初始低剂量DEC联合退烧药的14天DEC疗程可能更容易被接受。
