高度有效地脱保护碳水化合物的糖端氧原子上的 2,2,2-三氯乙基基团。
A highly efficient deprotection of the 2,2,2-trichloroethyl group at the anomeric oxygen of carbohydrates.
机构信息
Department of Chemistry, East China Normal University, Shanghai 200062, China.
出版信息
Carbohydr Res. 2011 Oct 18;346(14):2290-3. doi: 10.1016/j.carres.2011.08.007. Epub 2011 Aug 16.
PMID:21889124
Abstract
Commercially available zinc dust in the presence of ammonium chloride in acetonitrile at reflux removes the 2,2,2-trichloroethyl (TCE) group at anomeric centers with excellent yields (>95%) in short reaction times. This present method is easily implemented on substrates containing acyl and benzyl groups and large-scale reactions also proceed in high yield.
摘要
商业可得的锌粉在乙腈中的氯化铵存在下，回流条件下可在糖苷中心处除去 2,2,2-三氯乙基（TCE）基团，反应时间短，收率极高（>95%）。该方法易于在含有酰基和苄基的底物上实施，并且大规模反应也能以高产率进行。
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