Bavbek S, Yilmaz I, Celik G, Aydin O, Erkekol F Ö, Orman A, Kurt E, Ediger D, Dursun B, Abadoğlu O, Ozşeker F, Akkaya E, Karakiş G P, Canbakan S, Yüksel S, Misirligil Z
Ankara University, School of Medicine, Department of Chest Diseases, Division of Immunology and Allergy, Turkey.
Allergol Immunopathol (Madr). 2012 Jul-Aug;40(4):225-30. doi: 10.1016/j.aller.2011.05.015. Epub 2011 Sep 1.
There are no country-based data focused on aspirin (ASA)-exacerbated respiratory disease (AERD) in Turkey.
To assess the prevalence of AERD in adult patients with asthma.
A structured questionnaire was administered via face-to-face interview by a specialist in pulmonology/allergy at seven centres across Turkey.
A total of 1344 asthma patients (F/M: 1081/263: 80.5%/19.5%, mean age: 45.7 ± 14.2 years) were enrolled. Atopy rate was 47%. Prevalence of allergic rhinitis, chronic rhinosinusitis/rhinitis, and nasal polyposis (NP) were 49%, 69% and 20%, respectively. Of 270 patients with NP, 171 (63.3%) reported previous nasal polypectomy and 40 (25%) had a history of more than three nasal polypectomies. Aspirin hypersensitivity was diagnosed in 180 (13.6%) asthmatic patients, with a reliable history in 145 (80.5%), and oral ASA provocation test in 35 (19.5%) patients. Clinical presentations of ASA hypersensitivity were respiratory in 76% (n=137), respiratory/cutaneous in 15% (n=27), and systemic in 9% (n=16) of the patients. Multivariate analysis indicated that a family history of ASA hypersensitivity (p: 0.001, OR: 3.746, 95% CI: 1.769-7.929), history of chronic rhinosinusitis/rhinitis (p: 0.025, OR: 1.713, 95% CI: 1.069-2.746) and presence of NP (p<0.001, OR: 7.036, 95% CI: 4.831-10.247) were independent predictors for AERD.
This cross-sectional survey showed that AERD is highly prevalent among adult asthmatics and its prevalence seems to be affected by family history of ASA hypersensitivity, history of rhinosinusitis and presence of NP.
在土耳其，尚无基于国家层面针对阿司匹林（ASA）诱发的呼吸道疾病（AERD）的数据。
评估成人哮喘患者中AERD的患病率。
土耳其七个中心的肺科/过敏科专家通过面对面访谈的方式发放结构化问卷。
共纳入1344例哮喘患者（女/男：1081/263；80.5%/19.5%，平均年龄：45.7±14.2岁）。特应性率为47%。过敏性鼻炎、慢性鼻-鼻窦炎/鼻炎和鼻息肉（NP）的患病率分别为49%、69%和20%。在270例NP患者中，171例（63.3%）报告曾行鼻息肉切除术，40例（25%）有三次以上鼻息肉切除术史。180例（13.6%）哮喘患者被诊断为阿司匹林超敏反应，其中145例（80.5%）有可靠病史，35例（19.5%）患者进行了口服ASA激发试验。ASA超敏反应的临床表现中，76%（n=137）为呼吸道症状，15%（n=27）为呼吸道/皮肤症状，9%（n=16）为全身症状。多因素分析表明，ASA超敏反应家族史（p：0.001，OR：3.746，95%CI：1.769-7.929）、慢性鼻-鼻窦炎/鼻炎病史（p：0.025，OR：1.713，95%CI：1.069-2.746）和NP的存在（p<0.001，OR：7.036，95%CI：4.831-10.247）是AERD的独立预测因素。
这项横断面调查显示，AERD在成年哮喘患者中高度流行，其患病率似乎受ASA超敏反应家族史、鼻窦炎病史和NP的存在影响。
