Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Alcohol. 2012 Feb;46(1):107-14. doi: 10.1016/j.alcohol.2011.07.004. Epub 2011 Sep 1.
The annual meeting of the Fetal Alcohol Spectrum Disorders Study Group (FASDSG) was held on June 26, 2010 in San Antonio, TX, as a satellite of the Research Society on Alcoholism meeting. The FASDSG membership includes clinical, basic, and social scientists who meet to discuss recent advances and issues in Fetal Alcohol Spectrum Disorder (FASD) research. The central theme of the meeting was "Glia and Neurons: Teamwork in Pathology and Therapy." Alcohol disruption of neuron development and alcohol-induced neurodegeneration is central to the pathology and clinical expression of FASD. The active role of glia as perpetrator, victim, or bystander in neurotoxicology and neurodegenerative processes has emerged at the forefront of adult central nervous system (CNS) disorders and therapy. Glia- and neuron-glial interactions hold the potential to elucidate causes and offer treatment of FASD as well. Growing evidence indicates that neurons and glia are direct targets of alcohol, but may also be vulnerable to molecules produced in peripheral systems as a result of alcohol exposure. Diagnostics and therapies can take advantage of these processes and biomarkers, and these may be applicable to CNS pathology in FASD. Two keynote speakers, Howard E. Gendelman, M.D., and Ernest M. Graham, M.D, addressed the role of glia and neuroinflammation in brain development and neurodegeneration. The invited speakers and FASDSG members discussed new paradigms in CNS development and discuss new strategies for understanding and treating neurodegenerative disease. Members of the FASDSG provided updates on new findings through presentation of breaking research in the FASt data sessions. Representatives of national agencies provided updates on programs, activities, and funding priorities. The Henry Rosett Award was presented to R. Louise Floyd, R.N., D.S.N., for her career contributions to the field of fetal alcohol research. The Student and Postdoctoral Fellow Research Merit Award was presented to Shonagh O'Leary-Moore, Ph.D., for her contributions to the field as a young investigator.
胎儿酒精谱系障碍研究组（FASDSG）的年度会议于 2010 年 6 月 26 日在德克萨斯州圣安东尼奥市举行，作为酒精研究学会会议的一个卫星会议。FASDSG 的成员包括临床、基础和社会科学家，他们聚集在一起讨论胎儿酒精谱系障碍（FASD）研究的最新进展和问题。会议的主题是“神经胶质细胞和神经元：在病理和治疗中的协作”。酒精对神经元发育的破坏和酒精引起的神经退行性变是 FASD 病理和临床表现的核心。神经胶质细胞在神经毒性和神经退行性过程中的肇事者、受害者或旁观者的积极作用已成为成人中枢神经系统（CNS）疾病和治疗的前沿。神经胶质细胞和神经元-神经胶质细胞的相互作用有可能阐明 FASD 的病因并提供治疗方法。越来越多的证据表明，神经元和神经胶质细胞是酒精的直接靶点，但也可能易受酒精暴露引起的外周系统分子的影响。诊断和治疗可以利用这些过程和生物标志物，并且这些可能适用于 FASD 的中枢神经系统病理。两位主题演讲者，Howard E. Gendelman，医学博士和 Ernest M. Graham，医学博士，讨论了神经胶质细胞和神经炎症在大脑发育和神经退行性变中的作用。特邀演讲者和 FASDSG 成员讨论了 CNS 发育的新范例，并讨论了理解和治疗神经退行性疾病的新策略。FASDSG 成员通过在 FASt 数据会议上展示突破性研究提供了新发现的最新情况。国家机构的代表提供了有关计划、活动和资金优先事项的最新情况。Henry Rosett 奖授予 R. Louise Floyd，R.N.，D.S.N.，以表彰她在胎儿酒精研究领域的职业贡献。学生和博士后研究员研究卓越奖授予 Shonagh O'Leary-Moore，博士，以表彰她作为年轻研究员在该领域的贡献。
