铰链区、环 3 和环 4 在大肠杆菌环 AMP 受体蛋白激活中的作用。
Roles of hinge region, loops 3 and 4 in the activation of Escherichia coli cyclic AMP receptor protein.
机构信息
Department of Chemistry, Fudan University, Shanghai 200433, China.
出版信息
Int J Biol Macromol. 2012 Jan 1;50(1):1-6. doi: 10.1016/j.ijbiomac.2011.08.016. Epub 2011 Aug 25.
The cAMP receptor protein (CRP) requires cAMP for an allosteric change and regulates more than 150 genes in Escherichia coli. In this study, the modular half of cAMP receptor protein was used to investigate the allosteric signal transmission pathway induced by cAMP binding. The activation of CRP upon cAMP binding is indicated to be realignment of the two subunits within the CRP dimer. The interaction of loop 3 and Phe136 do not involve in signal transmission.
环腺苷酸受体蛋白（CRP）需要 cAMP 才能发生变构，并调节大肠杆菌中的 150 多个基因。在这项研究中，使用 cAMP 受体蛋白的模块半体来研究 cAMP 结合诱导的变构信号转导途径。cAMP 结合后 CRP 的激活表明 CRP 二聚体中两个亚基的重排。环 3 和 Phe136 的相互作用不参与信号传递。
Zotero 插件