Department of Medicine Austin Health/Northern Health, University of Melbourne, Heidelberg, Victoria 3084, Australia.
Endocrinol Metab Clin North Am. 2011 Sep;40(3):655-71, x. doi: 10.1016/j.ecl.2011.05.004.
Androgen deprivation therapy (ADT) is a major component of the contemporary management of prostate cancer. ADT's use is increasing rapidly. The side effects of this therapy include loss of bone mass and fractures, increase in fat mass, and worsening of insulin resistance, the metabolic syndrome, diabetes and cardiovascular risk, and anemia and loss of muscle. Neuropsychological and sexual symptoms are common. The impact of these side effects is often overlooked or underestimated in decisions about prostate cancer therapy. This review surveys the data relating to the side effects of ADT and provides recommendations regarding their minimization and management.
雄激素剥夺疗法（ADT）是当代前列腺癌治疗的主要手段之一。ADT 的应用正在迅速增加。该疗法的副作用包括骨量减少和骨折、体脂增加、胰岛素抵抗、代谢综合征、糖尿病和心血管风险恶化以及贫血和肌肉减少。神经心理和性功能障碍症状很常见。在决定前列腺癌治疗方案时，这些副作用的影响往往被忽视或低估。本综述调查了与 ADT 相关的副作用数据，并就其最小化和管理提供了建议。
